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  Mechanism of high-frequency signaling at a depressing ribbon synapse.

Grabner, C., Ratliff, C. P., Light, A. C., & DeVries, S. H. (2016). Mechanism of high-frequency signaling at a depressing ribbon synapse. Neuron, 91(1), 133-145. doi:10.1016/j.neuron.2016.05.019.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7E3B-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7E43-C
Genre: Journal Article

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 Creators:
Grabner, C.1, Author              
Ratliff, C. P., Author
Light, A. C., Author
DeVries, S. H., Author
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1Research Group of Synaptic Nanophysiology, MPI for Biophysical Chemistry, Max Planck Society, ou_2205655              

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 Abstract: Ribbon synapses mediate continuous release in neurons that have graded voltage responses. While mammalian retinas can signal visual flicker at 80-100 Hz, the time constant, tau, for the refilling of a depleted vesicle release pool at cone photoreceptor ribbons is 0.7-1.1 s. Due to this prolonged depression, the mechanism for encoding high temporal frequencies is unclear. To determine the mechanism of high-frequency signaling, we focused on an "Off" cone bipolar cell type in the ground squirrel, the cb2, whose transient postsynaptic responses recovered following presynaptic depletion with a tau of similar to 0.1 s, or 7- to 10-fold faster than the tau for presynaptic pool refilling. The difference in recovery time course is caused by AMPA receptor saturation, where partial refilling of the presynaptic pool is sufficient for a full postsynaptic response. By limiting the dynamic range of the synapse, receptor saturation counteracts ribbon depression to produce rapid recovery and facilitate high-frequency signaling.

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Language(s): eng - English
 Dates: 2016-06-092016-07-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuron.2016.05.019
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 91 (1) Sequence Number: - Start / End Page: 133 - 145 Identifier: -