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  Caloric restriction in older adults-differential effects of weight loss and reduced weight on brain structure and function

Prehn, K., Jumpertz von Schwartzenberg, R., Mai, K., Zeitz, U., Witte, V., Hampel, D., Szela, A.-M., Fabian, S., Grittner, U., Spranger, J., & Flöel, A. (2017). Caloric restriction in older adults-differential effects of weight loss and reduced weight on brain structure and function. Cerebral Cortex, 27(3), 1765-1778. doi:10.1093/cercor/bhw008.

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基本情報

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-81B0-1 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-36EE-B
資料種別: 学術論文

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関連URL

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URL:
https://doi.org/10.1093/cercor/bhw008 (出版社版)
説明:
-
OA-Status:
Green

作成者

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 作成者:
Prehn, Kristin1, 著者
Jumpertz von Schwartzenberg, Reiner2, 著者
Mai, Knut2, 著者
Zeitz, Ulrike2, 著者
Witte, Veronica1, 3, 著者           
Hampel, Dierk2, 著者
Szela , Anna-Maria1, 著者
Fabian, Sonja1, 著者
Grittner, Ulrike4, 5, 著者
Spranger, Joachim2, 著者
Flöel, Agnes1, 著者
所属:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Clinic of Endocrinolgy, Diabetes and Nutrition, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Biostatistics and Clinical Epidemiology, Charité University Medicine Berlin, Germany, ou_persistent22              
5Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

内容説明

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キーワード: Aging; Hippocampus; Nutritional intervention; Resting-state fMRI; VBM
 要旨: Dietary modifications such as caloric restriction (CR) have been suggested as a means to improve memory and prevent age-related decline. However, it is unclear whether those effects remain stable over time or are related specifically to negative energy balance during the weight loss phase of CR. Using a randomized interventional design, we investigated changes in recognition memory and neural correlates in postmenopausal obese women (n = 19): 1) after intense weight loss in the course of a 12-week low-caloric diet (reduced body weight and negative energy balance) and 2) after having sustained the reduced weight over 4 more weeks (reduced body weight, but energy balance equilibrium). Participants were contrasted to a control group (n = 18) instructed not to change dietary habits. In the CR group, we found improved recognition memory, paralleled by increased gray matter volume in inferior frontal gyrus and hippocampus, and augmented hippocampal resting-state functional connectivity to parietal areas. Moreover, effects were specific for transient negative energy balance and could not be detected after subsequent weight maintenance. Our data demonstrate for the first time in humans that beneficial effects of CR on brain structure and function are due to weight loss rather than an overall reduced weight.

資料詳細

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言語: eng - English
 日付: 2016-02-012017-03-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1093/cercor/bhw008
PMID: 26838769
 学位: -

関連イベント

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訴訟

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Project information

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Project name : -
Grant ID : HA-314
Funding program : -
Funding organization : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”
Project name : -
Grant ID : -
Funding program : Clinical Research Unit
Funding organization : Berlin Institute of Health (BIH)
Project name : -
Grant ID : Fl 379-8/1 ; Fl 379-10/1 ; Fl 379-11/1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : Hormonal regulation of body weight maintenance / KFO 218
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01EO0801 ; 01GQ1424A ; 01GQ1420B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)
Project name : -
Grant ID : -
Funding program : Charité Clinical Scientist Program
Funding organization : Berlin Instititute of Health (BIH)

出版物 1

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出版物名: Cerebral Cortex
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York, NY : Oxford University Press
ページ: - 巻号: 27 (3) 通巻号: - 開始・終了ページ: 1765 - 1778 識別子（ISBN, ISSN, DOIなど）: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440