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  Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients

Wirth, M., Pichet Binette, A., Brunecker, P., Köbe, T., Witte, V., & Flöel, A. (2017). Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients. Journal of Cerebral Blood Flow and Metabolism, 37(3), 814-824. doi:10.1177/0271678X16641128.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-81BA-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-36E1-8
Genre: Journal Article

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Locator:
https://journals.sagepub.com/doi/10.1177/0271678X16641128 (Publisher version)
Description:
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OA-Status:
Green

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 Creators:
Wirth, Miranka1, Author
Pichet Binette, Alexa1, 2, Author
Brunecker, Peter3, Author
Köbe, Theresa1, Author
Witte, Veronica1, 4, Author           
Flöel, Agnes1, 3, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Centre for Studies on Prevention of Alzheimer’s Disease, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Cerebral blood flow; Cerebral blood volume; Magnetic resonance imaging; Mild cognitive impairment; Alzheimer’s disease
 Abstract: Reductions of cerebral blood flow and gray matter structure have been implicated in early pathogenesis of Alzheimer’s disease, potentially providing complementary information. The present study evaluated regional patterns of cerebral hypoperfusion and atrophy in patients with mild cognitive impairment and healthy older adults. In each participant, cerebral perfusion and gray matter structure were extracted within selected brain regions vulnerable to Alzheimer’s disease using magnetic resonance imaging. Measures were compared between diagnostic groups with/without adjustment for covariates. In mild cognitive impairment patients, cerebral blood flow was significantly reduced in comparison with healthy controls in temporo-parietal regions and the basal ganglia in the absence of local gray matter atrophy. By contrast, gray matter structure was significantly reduced in the hippocampus in the absence of local hypoperfusion. Both, cerebral perfusion and gray matter structure were significantly reduced in the entorhinal and isthmus cingulate cortex in mild cognitive impairment patients compared with healthy older adults. Our results demonstrated partly divergent patterns of temporo-parietal hypoperfusion and medial-temporal atrophy in mild cognitive impairment patients, potentially indicating biomarker sensitivity to dissociable pathological mechanisms. The findings support applicability of cerebral perfusion and gray matter structure as complementary magnetic resonance imaging-based biomarkers in early Alzheimer’s disease detection, a hypothesis to be further evaluated in longitudinal studies.

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Language(s): eng - English
 Dates: 2016-01-272015-09-092016-02-252016-04-012017-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1177/0271678X16641128
PMID: 27037094
PMC: PMC5363461
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : Fl 379-8/1 ; Fl 379-10/1 ; Fl 379-11/1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 0315673A ; 01EO0801 ; 01GQ1424A ; 01GQ1420B
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : Hans Gerhard Creutzfeldt scholarship
Funding organization : -
Project name : NeuroCure – Neue Wege in der Erforschung und Behandlung von Erkrankungen des Nervensystems / EXC 2049
Grant ID : -
Funding program : NeuroCure Female postdoctoral research fellowship
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

Source 1

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 37 (3) Sequence Number: - Start / End Page: 814 - 824 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202