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  mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium.

Bachmann, C., Nguyen, H., Rosenbusch, J., Pham, L., Rabe, T., Patwa, M., et al. (2016). mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium. PLoS Genetics, 12(9): e1006274. doi:10.1371/journal.pgen.1006274.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-8176-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-818E-2
Genre: Journal Article

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 Creators:
Bachmann, C., Author
Nguyen, H., Author
Rosenbusch, J., Author
Pham, L., Author
Rabe, T.1, Author              
Patwa, M., Author
Sokpor, G., Author
Seong, R. H., Author
Ashery-Padan, R., Author
Mansouri, A.1, Author              
Stoykova, A.2, Author              
Staiger, J. F., Author
Tuoc, T., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              
2Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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 Abstract: Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively. We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs. We report that conditional deletion of BAF155, a core subunit in both onscBAF and ornBAF complexes, causes impaired proliferation of oNSCs as well as defective maturation and axonogenesis of ORNs in the developing olfactory epithelium (OE), while the high expression of BAF170 is important for maturation of ORNs. Interestingly, in the absence of BAF complexes in BAF155/BAF170 double-conditional knockout mice (dcKO), OE is not specified. Mechanistically, BAF complex is required for normal activation of Pax6-dependent transcriptional activity in stem cells/progenitors of the OE. Our findings unveil a novel mechanism mediated by the mSWI/SNF complex in OE neurogenesis and development.

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Language(s): eng - English
 Dates: 2016-09-09
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pgen.1006274
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Title: PLoS Genetics
Source Genre: Journal
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Pages: 29 Volume / Issue: 12 (9) Sequence Number: e1006274 Start / End Page: - Identifier: -