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  Model-free temporal-difference learning and dopamine in alcohol dependence: Examining concepts from theory and animals in human imaging

Huys, Q. J. M., Deserno, L., Obermayer, K., Schlagenhauf, F., & Heinz, A. (2016). Model-free temporal-difference learning and dopamine in alcohol dependence: Examining concepts from theory and animals in human imaging. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(5), 401-410. doi:10.1016/j.bpsc.2016.06.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-822D-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1A61-3
Genre: Journal Article

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 Creators:
Huys, Quentin J. M.1, 2, Author
Deserno, Lorenz3, 4, 5, Author              
Obermayer, Klaus6, Author
Schlagenhauf, Florian3, 4, Author              
Heinz, Andreas4, Author
Affiliations:
1Centre for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Zurich, Switzerland, ou_persistent22              
2Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Neural Information Processing Group, Department of Software Engineering and Theoretical Computer Science, TU Berlin, Germany, ou_persistent22              

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Free keywords: Alcohol; Computational psychiatry; Cue reactivity; Dopamine; Habits; Model-free; Reinforcement learning; Ventral striatum
 Abstract: Dopamine potentially unites two important roles: one in addiction, being involved in most substances of abuse including alcohol, and a second one in a specific type of learning, namely model-free temporal-difference reinforcement learning. Theories of addiction have long suggested that drugs of abuse may usurp dopamine’s role in learning. Here, we briefly review the preclinical literature to motivate specific hypotheses about model-free temporal-difference learning and then review the imaging evidence in the drug of abuse with the most substantial societal consequences: alcohol. Despite the breadth of the literature, only a few studies have examined the predictions directly, and these provide at best inconclusive evidence for the involvement of temporal-difference learning alterations in alcohol dependence. We discuss the difficulties of testing the theory in humans, make specific suggestions, and close with a focus on the interaction with other learning mechanisms.

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Language(s): eng - English
 Dates: 2016-06-092016-02-022016-06-142016-06-232016-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.bpsc.2016.06.005
PMID: 29560869
Other: Epub 2016
 Degree: -

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Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1 (5) Sequence Number: - Start / End Page: 401 - 410 Identifier: ISSN: 2451-9022
CoNE: /journals/resource/2451-9022