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  Behavioral and neural signatures of reduced updating of alternative options in alcohol-dependent patients during flexible decision-making

Reiter, A., Deserno, L., Kallert, T., Heinze, H.-J., Heinz, A., & Schlagenhauf, F. (2016). Behavioral and neural signatures of reduced updating of alternative options in alcohol-dependent patients during flexible decision-making. The Journal of Neuroscience, 36(43), 10935-10948. doi:10.1523/JNEUROSCI.4322-15.2016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-8261-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1EEB-4
Genre: Journal Article

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 Creators:
Reiter, Andrea1, 2, 3, Author              
Deserno, Lorenz1, 4, 5, Author              
Kallert, Thomas6, Author
Heinze, Hans-Jochen1, 5, 7, Author
Heinz, Andreas4, Author
Schlagenhauf, Florian1, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany, ou_persistent22              
3Lifespan Developmental Neuroscience, Department of Psychology, TU Dresden, Germany, ou_persistent22              
4Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Soteria Clinic Leipzig, Germany, ou_persistent22              
7Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              

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 Abstract: Addicted individuals continue substance use despite the knowledge of harmful consequences and often report having no choice but to consume. Computational psychiatry accounts have linked this clinical observation to difficulties in making flexible and goal-directed decisions in dynamic environments via consideration of potential alternative choices. To probe this in alcohol-dependent patients ( n 43) versus healthy volunteers ( n 35), human participants performed an anticorrelated decision-making task during functional neuroimaging. Via computational modeling, we investigated behavioral and neural signatures of inference regarding the alternative option. While healthy control subjects exploited the anticorrelated structure of the task to guide decision-making, alcohol-dependent patients were relatively better explained by a model-free strategy due to reduced inference on the alternative option after punishment. Whereas model-free prediction error signals were preserved, alcohol-dependent patients exhibited blunted medial prefrontal signatures of inference on the alternative option. This reduction was associated with patients’ behavioral deficit in updating the alternative choice option and their obsessive-compulsive drinking habits. All results remained significant when adjusting for potential confounders (e.g., neuropsychological measures and gray matter density). A disturbed integration of alternative choice options implemented by the medial prefrontal cortex appears to be one important explanation for the puzzling question of why addicted individuals continue drug consump- tion despite negative consequences.

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Language(s): eng - English
 Dates: 2016-08-072015-11-302016-08-142016-10-26
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.4322-15.2016
PMID: 27798176
 Degree: -

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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 36 (43) Sequence Number: - Start / End Page: 10935 - 10948 Identifier: ISSN: 0270-6474
CoNE: /journals/resource/954925502187_1