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  FBXO3 protein promotes ubiquitylation and transcriptional activity of AIRE (Autoimmune Regulator).

Shao, W., Zumer, K., Fujinaga, K., & Peterlin, B. M. (2016). FBXO3 protein promotes ubiquitylation and transcriptional activity of AIRE (Autoimmune Regulator). Journal of Biological Chemistry, 291(34), 17953-17963. doi:10.1074/jbc.M116.724401.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-834A-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-87E6-F
Genre: Journal Article

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 Creators:
Shao, W., Author
Zumer, K.1, Author              
Fujinaga, K., Author
Peterlin, B. M., Author
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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Free keywords: Autoimmunity; Gene regulation; Protein phosphorylation; Transcription factor; Ubiquitylation (ubiquitination); AIRE; FBXO3; P-TEFb
 Abstract: The autoimmune regulator (AIRE) is a transcription factor which is expressed in medullary thymic epithelial cells. It directs the expression of otherwise tissue-specific antigens, which leads to the elimination of autoreactive T cells during development. AIRE is modified post-translationally by phosphorylation and ubiquitylation. In this report we connected these modifications. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCFFBXO3 (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. Because P-TEFb is required for the transition from initiation to elongation of transcription, this interaction ensures proper expression of AIRE-responsive tissue-specific antigens in the thymus.

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Language(s): eng - English
 Dates: 2016-06-302016-08-19
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1074/jbc.M116.724401
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Title: Journal of Biological Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 291 (34) Sequence Number: - Start / End Page: 17953 - 17963 Identifier: -