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  Feasibility and acceptance of simultaneous amyloid PET/MRI

Schütz, L., Lobsien, D., Fritzsch, D., Tiepolt, S., Werner, P., Schroeter, M. L., et al. (2016). Feasibility and acceptance of simultaneous amyloid PET/MRI. European Journal of Nuclear Medicine and Molecular Imaging, 43(12), 2236-2243. doi:10.1007/s00259-016-3462-x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-847C-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19ED-7
Genre: Journal Article

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 Creators:
Schütz, Lisa1, Author
Lobsien, Donald2, Author
Fritzsch, Dominik2, Author
Tiepolt, Solveig1, Author
Werner, Peter1, Author
Schroeter, Matthias L.3, 4, 5, Author              
Berrouschot, Jörg6, Author
Saur, Dorothee7, Author
Hesse, Swen1, 5, Author
Jochimsen, Thies1, Author
Rullmann, Michael1, Author              
Sattler, Bernhard1, Author
Patt, Marianne1, Author
Gertz, Hermann-Josef8, Author
Villringer, Arno3, 4, 5, Author              
Claßen, Joseph7, Author
Hoffmann, Karl-Titus2, Author
Sabri, Osama1, 5, Author
Barthel, Henryk1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
6Clinical Centre Altenburger Land, Altenburg, Germany, ou_persistent22              
7Department of Neurology, University of Leipzig, Germany, ou_persistent22              
8Department of Psychiatry, University of Leipzig, Germany, ou_persistent22              

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Free keywords: PET/MRI; Amyloid; Alzheimer’s disease; MCI
 Abstract: Purpose Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative concepts classify into diagnostic and progression AD biomarkers. However, combined amyloid positron emission tomography/magnetic resonance imaging (PET/MRI) offers the chance to obtain both biomarker category read-outs within one imaging session, with increased patient as well as referrer convenience. The aim of this pilot study was to investigate this matter for the first time. Methods 100 subjects (age 70 ± 10 yrs, 46 female), n = 51 with clinically defined mild cognitive impairment (MCI), n = 44 with possible/probable AD dementia, and n = 5 with frontotemporal lobe degeneration, underwent simultaneous [18F]florbetaben or [11C]PIB PET/MRI (3 Tesla Siemens mMR). Brain amyloid load, mesial temporal lobe atrophy (MTLA) by means of the Scheltens scale, and other morphological brain pathologies were scored by respective experts. The patients/caregivers as well as the referrers were asked to assess on a five-point scale the convenience related to the one-stop-shop PET and MRI approach. Results In three subjects, MRI revealed temporal lobe abnormalities other than MTLA. According to the National Institute on Aging-Alzheimer’s Association classification, the combined amyloid-beta PET/MRI evaluation resulted in 31 %, 45 %, and 24 % of the MCI subjects being categorized as “MCI-unlikely due to AD”, “MCI due to AD-intermediate likelihood”, and “MCI due to AD-high likelihood”, respectively. 50 % of the probable AD dementia patients were categorized as “High level of evidence of AD pathophysiological process”, and 56 % of the possible AD dementia patients as “Possible AD dementia - with evidence of AD pathophysiological process”. With regard to the International Working Group 2 classification, 36 subjects had both positive diagnostic and progression biomarkers. The patient/caregiver survey revealed a gain of convenience in 88 % of responders as compared to a theoretically separate PET and MR imaging. In the referrer survey, an influence of the combined amyloid-beta PET/MRI on the final diagnosis was reported by 82 % of responders, with a referrer acceptance score of 3.7 ± 1.0 on a 5-point scale. Conclusion Simultaneous amyloid PET/MRI is feasible and provides imaging biomarkers of all categories which are able to supplement the clinical diagnosis of MCI due to AD and that of AD dementia. Further, patient and referrer convenience is improved by this one-stop-shop imaging approach.

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Language(s): eng - English
 Dates: 2016-05-132016-07-062016-07-192016-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00259-016-3462-x
PMID: 27435367
Other: Epub 2016
 Degree: -

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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Publ. Info: Heidelberg, Germany : Springer
Pages: - Volume / Issue: 43 (12) Sequence Number: - Start / End Page: 2236 - 2243 Identifier: ISSN: 1619-7070
CoNE: /journals/resource/954925519624