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  In-vivo dynamics of the human hippocampus across the menstrual cycle

Barth, C., Steele, C., Mueller, K., Rekkas, V. P., Arelin, K., Pampel, A., et al. (2016). In-vivo dynamics of the human hippocampus across the menstrual cycle. Scientific Reports, 6: 32833. doi:10.1038/srep32833.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-854A-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1E51-1
Genre: Journal Article

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 Creators:
Barth, Claudia1, Author              
Steele, Christopher1, 2, Author              
Mueller, Karsten3, Author              
Rekkas, Vivien P.4, Author
Arelin, Katrin1, 5, 6, Author              
Pampel, André3, Author              
Burmann, Inga1, Author              
Kratzsch, Jürgen7, Author
Villringer, Arno1, 5, 6, 8, 9, Author              
Sacher, Julia1, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Campbell Family Mental Health Research Institute, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
7Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
8Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
9Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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 Abstract: Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impact of subtle sex-hormonal fluctuations on human hippocampal structure in health is unclear. We tested the feasibility of longitudinal neuroimaging in conjunction with rigorous menstrual cycle monitoring to evaluate potential changes in hippocampal microstructure associated with physiological sex-hormonal changes. Thirty longitudinal diffusion weighted imaging scans of a single healthy female subject were acquired across two full menstrual cycles. We calculated hippocampal fractional anisotropy (FA), a measure sensitive to changes in microstructural integrity, and investigated potential correlations with estrogen. We observed a significant positive correlation between FA values and estrogen in the hippocampus bilaterally, revealing a peak in FA closely paralleling ovulation. This exploratory, single-subject study demonstrates the feasibility of a longitudinal DWI scanning protocol across the menstrual cycle and is the first to link subtle endogenous hormonal fluctuations to changes in FA in vivo. In light of recent attempts to neurally phenotype single humans, our findings highlight menstrual cycle monitoring in parallel with highly sampled individual neuroimaging data to address fundamental questions about the dynamics of plasticity in the adult brain.

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Language(s): eng - English
 Dates: 2016-04-052016-08-112016-10-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/srep32833
PMID: 27713470
PMC: PMC5054394
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 32833 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322