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  Inhibition of information flow to the default mode network during self-reference versus reference to others

Soch, J., Deserno, L., Assmann, A., Barmann, A., Walter, H., Richardson-Klavehn, A., et al. (2017). Inhibition of information flow to the default mode network during self-reference versus reference to others. Cerebral Cortex, 27(8), 3930-3942. doi:10.1093/cercor/bhw206.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-85DB-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C7BF-6
Genre: Journal Article

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 Creators:
Soch, Joram1, 2, 3, Author
Deserno, Lorenz2, 4, 5, Author              
Assmann, Anne1, 5, Author
Barmann, Adriana1, Author
Walter, Henrik2, Author
Richardson-Klavehn, Alan5, Author
Schott, Björn1, 2, 5, 6, Author
Affiliations:
1Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              
2Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
3Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              

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Free keywords: Default mode network; Dynamic causal modeling; Effective connectivity; Self-reference; Social cognition
 Abstract: The default mode network (DMN), a network centered around the cortical midline, shows deactivation during most cognitive tasks and pronounced resting-state connectivity, but is actively engaged in self-reference and social cognition. It is, however, yet unclear how information reaches the DMN during social cognitive processing. Here, we addressed this question using dynamic causal modeling (DCM) of functional magnetic resonance imaging (fMRI) data acquired during self-reference (SR) and reference to others (OR). Both conditions engaged the left inferior frontal gyrus (LIFG), most likely reflecting semantic processing. Within the DMN, self-reference preferentially elicited rostral anterior cingulate and ventromedial prefrontal cortex (rACC/vmPFC) activity, whereas OR engaged posterior cingulate and precuneus (PCC/PreCun). DCM revealed that the regulation of information flow to the DMN was primarily inhibitory. Most prominently, SR elicited inhibited information flow from the LIFG to the PCC/PreCun, while OR was associated with suppression of the connectivity from the LIFG to the rACC/vmPFC. These results suggest that task-related DMN activation is enabled by inhibitory down-regulation of task-irrelevant information flow when switching from rest to stimulus-specific processing.

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Language(s): eng - English
 Dates: 2016-03-182016-05-062016-07-112017-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhw206
PMID: 27405334
 Degree: -

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Project name : Neurobiologie motivierten Verhaltens / SFB 779
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Funding program : -
Funding organization : German Research Foundation (DFG)
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Grant ID : -
Funding program : Leibniz Graduate School on SynaptoGenetics (LGS)
Funding organization : Leibniz Association

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 27 (8) Sequence Number: - Start / End Page: 3930 - 3942 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440