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  Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells

Beining, M., Jungenitz, T., Radic, T., Deller, T., Cuntz, H., Jedlicka, P., et al. (2016). Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells. Brain structure & function. doi:http://dx.doi.org/10.1007/s00429-016-1285-y.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8765-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-1162-0
Genre: Journal Article
Alternative Title : Brain structure & function

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 Creators:
Beining, M.1, Author
Jungenitz, T.2, Author
Radic, T.2, Author
Deller, T.2, Author
Cuntz, H.1, Author
Jedlicka, P.2, Author
Schwarzacher, S. W.2, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2external, ou_persistent22              

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 Abstract: Adult-born dentate granule cells (abGCs) exhibit a critical developmental phase during function integration. The time window of this phase is debated and whether abGCs become indistinguishable from developmentally born mature granule cells (mGCs) is uncertain. We analyzed complete dendritic reconstructions from abGCs and mGCs using viral labeling. AbGCs from 21-77 days post intrahippocampal injection (dpi) exhibited comparable dendritic arbors, suggesting that structural maturation precedes functional integration. In contrast, significant structural differences were found compared to mGCs: AbGCs had more curved dendrites, more short terminal segments, a different branching pattern, and more proximal terminal branches. Morphological modeling attributed these differences to developmental dendritic pruning and postnatal growth of the dentate gyrus. We further correlated GC morphologies with the responsiveness to unilateral medial perforant path stimulation using the immediate-early gene Arc as a marker of synaptic activation. Only abGCs at 28 and 35 dpi but neither old abGCs nor mGCs responded to stimulation with a remodeling of their dendritic arbor. Summarized, abGCs stay distinct from mGCs and their dendritic arbor can be shaped by afferent activity during a narrow critical time window.

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 Dates: 2016
 Publication Status: Issued
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 Identifiers: URI: http://www.ncbi.nlm.nih.gov/pubmed/27514866http://download.springer.com/static/pdf/849/art%253A10.1007%252Fs00429-016-1285-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00429-016-1285-y&token2=exp=1472812823~acl=%2Fstatic%2Fpdf%2F849%2Fart%25253A10.1007%25252Fs00429-016-1285-y.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00429-016-1285-y*~hmac=889a69c9acbcc055c2ab6bab0bd21339bf69d225079367863cbb25e23af9c462
URI: internal-pdf://Beining-2016-Adult-born dentate g-3961859584/Beining-2016-Adult-born dentate g.pdf
Other: 1423
DOI: http://dx.doi.org/10.1007/s00429-016-1285-y
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Title: Brain structure & function
  Alternative Title : Brain structure & function
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 1863-2661 (Electronic)1863-2653 (Linking)