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  Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

Varela-Aramburu, S., Wirth, R., Lai, C.-H., Orts-Gil, G., & Seeberger, P. H. (2016). Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters. Beilstein Journal of Nanotechnology, 7, 1278-1283. doi:10.3762/bjnano.7.118.

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 Creators:
Varela-Aramburu, Silvia1, Author              
Wirth, Richard, Author
Lai, Chian-Hui2, Author              
Orts-Gil, Giullermo1, Author              
Seeberger, Peter H.2, Author              
Affiliations:
1Peter H. Seeberger - Nanoparticles and Colloidal Polymers, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863307              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: Open Access
 Abstract: Gold nanoclusters are small (1–3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and robust room temperature one-pot synthesis of 2 nm gold nanoclusters using thioglucose as a reducing and stabilizing agent, which was discovered by serendipity. The resultant monodisperse gold nanoclusters are more stable than those generated using some other common methods. The carboxylic acid contained in the stabilizing agent on the cluster surface serves as anchor for nanocluster functionalization. Alternatively, the addition of thiols serves to functionalize the nanoclusters. The resulting non-cytotoxic nanoclusters are taken up by cells and constitute a tuneable platform for biomedical applications including drug delivery.

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 Dates: 2016
 Publication Status: Published in print
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 Identifiers: DOI: 10.3762/bjnano.7.118
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Title: Beilstein Journal of Nanotechnology
Source Genre: Journal
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Publ. Info: Frankfurt am Main : Beilstein-Institut
Pages: - Volume / Issue: 7 Sequence Number: - Start / End Page: 1278 - 1283 Identifier: ISSN: 2190-4286