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Free keywords:
proline; aminocatalysis; enamine catalysis; iminium ion catalysis
Abstract:
During the last eleven years, aminocatalysis, the catalysis of carbonyl transformations via iminium ion and enamine intermediates has become a highly successful and general approach to asymmetric synthesis. There are now several dozens of different reaction types with hundreds of variants that are mediated by primary and secondary amine catalysts, of which proline continues to be a privileged motif. This Cluster highlights recent attempts towards solving some of the remaining challenges in the area.
