Central Apelin controls Glucose Homeostasis via a Nitric Oxide-Dependent 
Pathway in Mice

Duparc, Thibaut; Colom, André; Cani, Patrice D.; Massaly, Nicolas; Rastrelli, Sophie; Drougard, Anne; Le Gonidec, Sophie; Moulédous, Lionel; Frances, Bernard; Leclercq, Isabelle; Llorens-Cortes, Catherine; Pospisilik, Andrew J.; Delzenne, Nathalie M.; Valet, Philippe; Castan-Laurell, Isabelle; Knauf, Claude

Local TagsRelease HistoryDetailsSummary

Central Apelin controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

Duparc, T., Colom, A., Cani, P. D., Massaly, N., Rastrelli, S., Drougard, A., et al. (2011). Central Apelin controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice. Antioxidants & Redox Signaling, 15, 1477-1496.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-974B-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-974C-3

Genre: Journal Article

Files

show Files

Locators

show

Creators

show

hide

Creators:
Duparc, Thibaut, Author
Colom, André, Author
Cani, Patrice D., Author
Massaly, Nicolas, Author
Rastrelli, Sophie, Author
Drougard, Anne, Author
Le Gonidec, Sophie, Author
Moulédous, Lionel, Author
Frances, Bernard, Author
Leclercq, Isabelle, Author
Llorens-Cortes, Catherine, Author
Pospisilik, Andrew J.¹, Author
Delzenne, Nathalie M., Author
Valet, Philippe, Author
Castan-Laurell, Isabelle, Author
Knauf, Claude, Author

Affiliations:
1Max Planck Society, ou_persistent13

Content

show

hide

Free keywords: -

Abstract: AIMS: Apelin and its receptor have emerged as promising targets for the treatment of insulin resistance. Indeed, peripheral administration of apelin stimulates glucose utilization and insulin sensitivity via a nitric oxide (NO) pathway. In addition to being expressed on peripheral metabolically active adipose tissues, apelin is also found in the brain. However, no data are available on the role of central effects of apelin on metabolic control. We studied glucose metabolism in response to acute and chronic intracerebroventricular (i.c.v.) injection of apelin performed in normal and obese/diabetic mice. RESULTS: We demonstrate that i.c.v. injection of apelin into fed mice improves glucose control via NO-dependent mechanisms. These results have been strengthened by transgenic (eNOS-KO mice), pharmacological (L-NMMA i.c.v. treated mice), and real-time measurement of NO release with amperometric probes detection. High-fat diet-fed mice displayed a severely blunted response to i.c.v. apelin associated with a lack of NO response by the hypothalamus. Moreover, central administration of high dose apelin in fasted normal mice provoked hyperinsulinemia, hyperglycemia, glucose intolerance, and insulin resistance. CONCLUSION: These data provide compelling evidence that central apelin participates in the regulation of glucose homeostasis and suggest a novel pathophysiological mechanism involved in the transition from normal to diabetic state.

Details

show

hide

Language(s): eng - English

Dates: Date issued: 2011

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: Peer

Identifiers: eDoc: 576711

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: Antioxidants & Redox Signaling

Source Genre: Journal

Creator(s):

Affiliations:

Publ. Info: -

Pages: - Volume / Issue: 15 Sequence Number: - Start / End Page: 1477 - 1496 Identifier: -