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  RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J

Wacker, S. A., Cristobal, A., von Wichert, G., Knippschild, U., Wiedenmann, J., Clauß, K., et al. (2011). RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. The EMBO Journal, 30, 43-56.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-974D-1 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-974E-0
Genre: Zeitschriftenartikel

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 Urheber:
Wacker, Stephan Armin, Autor
Cristobal, Alvarado, Autor
von Wichert, Götz, Autor
Knippschild, Uwe, Autor
Wiedenmann, Jörg, Autor
Clauß, Karen, Autor
Nienhaus, Gerd Ulrich, Autor
Hameister, Horst, Autor
Baumann, Bernd, Autor
Borgreffe, Tilman1, Autor
Knöchel, Walter, Autor
Oswald, Franz, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

Inhalt

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Schlagwörter: neurogenesis; notch; nucleo-cytoplasmic shuttling; RBP-J; Xenopus
 Zusammenfassung: The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain (NICD). In the nucleus, NICD binds to the recombina-tion signal sequence-binding protein J (RBP-J)/CBF-1 transcription factor to induce expression of Notch target genes. Here, we report the identification and functional characterization of RBP-J interacting and tubulin associated (RITA) (C12ORF52) as a novel RBP-J/CBF-1-interacting protein. RITA is a highly conserved 36 kDa protein that, most interestingly, binds to tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus. This shuttling RITA exports RBP-J/CBF-1 from the nucleus. Functionally, we show that RITA can reverse a Notch-induced loss of primary neurogenesis in Xenopus laevis. Furthermore, RITA is able to downregulate Notch-mediated transcription. Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting.

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Sprache(n): eng - English
 Datum: 2011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 578728
 Art des Abschluß: -

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Titel: The EMBO Journal
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 30 Artikelnummer: - Start- / Endseite: 43 - 56 Identifikator: -