Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study

Kharabian, S., Herzig, S., Klose, L., Roggenhofer, E., Tenckhoff, H., Kaiser, T., et al. (2017). Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study. Journal of Viral Hepatitis, 24(3), 216-225. doi:10.1111/jvh.12634.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kharabian, Shahrzad1, Autor           
Herzig, Sabine2, Autor
Klose, Lisa2, Autor
Roggenhofer, Elisabeth1, Autor           
Tenckhoff, Hannelore2, Autor
Kaiser, Thorsten2, Autor
Thöne-Otto, Angelika2, Autor
Wiese, Manfred2, Autor
Berg, Thomas2, Autor
Schroeter, Matthias L.1, Autor           
Margulies, Daniel S.3, Autor           
Villringer, Arno1, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2External Organizations, ou_persistent22              
3Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

Inhalt

einblenden:
ausblenden:
Schlagwörter: chronic hepatitis-C; cognitive performance; graph centrality; resting state fMRI; voxel-based morphometry
 Zusammenfassung: Chronic hepatitis C virus (HCV) infection is associated with fatigue and depression. Cognitive impairments are also reported in a smaller number of HCV-positive patients. Recent studies linked HCV to low-grade inflammation in brain. Here, we test the hypothesis that chronic HCV is associated with 3T-neuroimaging-derived grey matter volume (GMV) and functional connectivity alterations in a sample of chronic HCV (1b), without severe liver disease. Regional GMV and resting-state fMRI-derived eigenvector centrality (EC) were compared between 19 HCV-positive patients and 23 healthy controls (all females, 50-69 and 52-64 years, respectively), controlling for white matter hyperintensities and age. Standard tests were used to assess fatigue, depression and cognitive performance. Also, liver fibrosis stage and viral load were quantified among patients. In comparison with controls, HCV-positive patients had higher scores in fatigue and depression, and worse alertness scores. The groups performed similarly in other cognitive domains. We report higher EC in a cluster in the right anterior superior parietal lobule in patients, while no differences are found in GMV. Post hoc functional connectivity analysis showed increased connectivity of this cluster with primary and secondary somatosensory cortex, and temporal and occipital lobes in patients. Higher mean EC in the superior parietal cluster, adjusted for mean framewise displacement, was associated with better memory and attention performance, but not with fatigue, depression, viral load or level of liver fibrosis, among patients. These results suggest a compensatory mechanism in chronic hepatitis C and explain equivocal results in the literature about cognitive deficits in infected persons. Further studies should define the relation of these connectivity changes to the brain's inflammatory activity.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2016-07-252016-10-052016-11-042017-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1111/jvh.12634
PMID: 27813284
Anderer: Epub 2016
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Institute for Cognitive and Brain Sciences

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Viral Hepatitis
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Wiley
Seiten: - Band / Heft: 24 (3) Artikelnummer: - Start- / Endseite: 216 - 225 Identifikator: ISSN: 1352-0504
CoNE: https://pure.mpg.de/cone/journals/resource/1352-0504