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  Stimulation of subgenual cingulate area decreases limbic top-down effect on ventral visual stream: A DBS-EEG pilot study

Kibleur, A., Polosan, M., Favre, P., Rudrauf, D., Bougerol, T., Chabardès, S., et al. (2017). Stimulation of subgenual cingulate area decreases limbic top-down effect on ventral visual stream: A DBS-EEG pilot study. NeuroImage, 146, 544-553. doi:10.1016/j.neuroimage.2016.10.018.

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 Creators:
Kibleur, Astrid1, 2, 3, Author
Polosan, Mircea1, 2, 3, 4, Author
Favre, Pauline1, 3, 5, Author              
Rudrauf, David1, 2, 3, Author
Bougerol, Thierry1, 2, 3, 4, Author
Chabardès, Stéphan1, 2, 3, 5, Author
David, Olivier1, 2, 3, Author
Affiliations:
1Université Grenoble Alpes, France, ou_persistent22              
2Institut national de la santé et de la recherche médicale, Université Grenoble Alpes, France, ou_persistent22              
3Clinique Universitaire de Neurochirurgie, Centre Hospitalier Universitaire de Grenoble, France, ou_persistent22              
4Clinique Universitaire de Psychiatrie, Centre Hospitalier Universitaire de Grenoble, France, ou_persistent22              
5Laboratory of Psychology and Neurocognition, Université Grenoble Alpes, France, ou_persistent22              

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Free keywords: Deep brain stimulation; Depression; EEG; Stroop effect; Anterior cingulate cortex
 Abstract: Deep brain stimulation (DBS) of the subgenual cingulate gyrus (area CG25) is beneficial in treatment resistant depression. Though the mechanisms of action of Cg25 DBS remain largely unknown, it is commonly believed that Cg25 DBS modulates limbic activity of large networks to achieve thymic regulation of patients. To investigate how emotional attention is influenced by Cg25 DBS, we assessed behavioral and electroencephalographic (EEG) responses to an emotional Stroop task in 5 patients during ON and OFF stimulation conditions. Using EEG source localization, we found that the main effect of DBS was a reduction of neuronal responses in limbic regions (temporal pole, medial prefrontal and posterior cingulate cortices) and in ventral visual areas involved in face processing. In the dynamic causal modeling (DCM) approach, the changes of the evoked response amplitudes are assumed to be due to changes of long range connectivity induced by Cg25 DBS. Here, using a simplified neural mass model that did not take explicitly into account the cytoarchitecture of the considered brain regions, we showed that the remote action of Cg25 DBS could be explained by a reduced top-down effective connectivity of the amygdalo-temporo-polar complex. Overall, our results thus indicate that Cg25 DBS during the emotional Stroop task causes a decrease of top-down limbic influence on the ventral visual stream itself, rather than a modulation of prefrontal cognitive processes only. Tuning down limbic excitability in relation to sensory processing might be one of the biological mechanisms through which Cg25 DBS produces positive clinical outcome in the treatment of resistant depression.

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Language(s): eng - English
 Dates: 2016-04-292016-10-112016-10-132017-02-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2016.10.018
PMID: 27743900
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : ANR-14-CE13-0030-01
Funding program : -
Funding organization : Agence Nationale pour la Recherche (ANR)
Project name : Infrastructure d’avenir en Biologie Santé
Grant ID : ANR-11-INBS-0006
Funding program : Investissement d’Avenir
Funding organization : Agence Nationale de la Recherche (ANR)
Project name : -
Grant ID : FDT20150532565
Funding program : -
Funding organization : Fondation pour la Recherche Médicale

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 146 Sequence Number: - Start / End Page: 544 - 553 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166