ausblenden:
Schlagwörter:
deoxygenation - catalysis - silane - carbohydrates - diols
Zusammenfassung:
The selective deoxygenation of polyols is an important frontier in our ability to transform biomass-derived compounds and other synthetic intermediates. In this Synpacts article, recent approaches using a B(C6F5)3/silane combination to site-selectively deoxygenate polyols are highlighted. First, the work of Gagné and coworkers is discussed. They developed a partial, selective deoxygenation of biologically sourced polyols proceeding through an elegant example of anchimeric assistance. In the second part, we present our recent work describing a catalytic deoxygenation of terminal diols with selectivity for the cleavage of the primary hydroxyl group. This transformation was enabled by the strategic formation of a cyclic siloxane intermediate.
