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  Mechanisms of aneuploidy in human eggs.

Webster, A., & Schuh, M. (2017). Mechanisms of aneuploidy in human eggs. Trends in Cell Biology, 27(1), 55-68. doi:10.1016/j.tcb.2016.09.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-A79C-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-65AF-5
Genre: Journal Article

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2353970.pdf (Publisher version), 3MB
 
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 Creators:
Webster, A.1, Author              
Schuh, M.1, Author              
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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Free keywords: aging; aneuploidy; chromosome segregation; human fertility; meiosis; oocyte
 Abstract: Eggs and sperm develop through a specialized cell division called meiosis. During meiosis, the number of chromosomes is reduced by two sequential divisions in preparation for fertilization. In human female meiosis, chromosomes frequently segregate incorrectly, resulting in eggs with an abnormal number of chromosomes. When fertilized, these eggs give rise to aneuploid embryos that usually fail to develop. As women become older, errors in meiosis occur more frequently, resulting in increased risks of infertility, miscarriage, and congenital syndromes, such as Down's syndrome. Here, we review recent studies that identify the mechanisms causing aneuploidy in female meiosis, with a particular emphasis on studies in humans.

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Language(s): eng - English
 Dates: 2016-09-272017-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tcb.2016.09.002
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Title: Trends in Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 27 (1) Sequence Number: - Start / End Page: 55 - 68 Identifier: -