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  In need of constraint: Understanding the role of the cingulate cortex in the impulsive mind

Golchert, J., Smallwood, J., Jefferies, E., Liem, F., Huntenburg, J. M., Falkiewicz, M., et al. (2017). In need of constraint: Understanding the role of the cingulate cortex in the impulsive mind. NeuroImage, 146, 804-813. doi:10.1016/j.neuroimage.2016.10.041.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-AEBE-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C669-8
Genre: Journal Article

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 Creators:
Golchert, Johannes1, Author           
Smallwood, Jonathan2, Author           
Jefferies, Elizabeth2, Author
Liem, Franz1, Author           
Huntenburg, Julia M.1, 3, Author           
Falkiewicz, Marcel1, Author           
Lauckner, Mark1, Author
Oligschläger, Sabine1, Author           
Villringer, Arno4, 5, Author           
Margulies, Daniel S.1, Author           
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2Department of Psychology, University of York, Heslington, United Kingdom, ou_persistent22              
3Neurocomputation and Neuroimaging Unit, FU Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Impulsivity; UPPS-P; Functional connectivity; Anterior cingulate cortex; Multiple demand network
 Abstract: Impulsive behavior often occurs without forethought and can be driven by strong emotions or sudden impulses, leading to problems in cognition and behavior across a wide range of situations. Although neuroimaging studies have explored the neurocognitive indicators of impulsivity, the large-scale functional networks that contribute to different aspects of impulsive cognition remain unclear. In particular, we lack a coherent account of why impulsivity is associated with such a broad range of different psychological features. Here, we use resting state functional connectivity, acquired in two independent samples, to investigate the neural substrates underlying different aspects of self-reported impulsivity. Based on the involvement of the anterior cingulate cortex (ACC) in cognitive but also affective processes, five seed regions were placed along the caudal to rostral gradient of the ACC. We found that positive urgency was related to functional connectivity between subgenual ACC and bilateral parietal regions such as retrosplenial cortex potentially highlighting this connection as being important in the modulation of the non-prospective, hastiness - related aspects of impulsivity. Further, two impulsivity dimensions were associated with significant alterations in functional connectivity of the supragenual ACC: (i) lack of perseverance was positively correlated to connectivity with the bilateral dorsolateral prefrontal cortex and right inferior frontal gyrus and (ii) lack of premeditation was inversely associated with functional connectivity with clusters within bilateral occipital cortex. Further analysis revealed that these connectivity patterns overlapped with bilateral dorsolateral prefrontal and bilateral occipital regions of the multiple demand network, a large-scale neural system implicated in the general control of thought and action. Together these results demonstrate that different forms of impulsivity have different neural correlates, which are linked to the functional connectivity of a region of anterior cingulate cortex. This suggests that poor perseveration and premeditation might be linked to dysfunctions in how the rostral zone of the ACC interacts with the multiple demand network that allows cognition to proceed in a controlled way.

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Language(s): eng - English
 Dates: 2016-09-202016-05-272016-10-242016-10-272017-02-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2016.10.041
PMID: 27989844
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : BB/J006963/1
Funding program : -
Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)
Project name : Wedding bells or bedding wells? Lexical and semantic influences on phoneme binding / SEMBIND
Grant ID : 283530
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : P2ZHP1_155200
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : Not all minds that wander are lost: A neurocognitive test of mind-wandering state’s contribution to human cognition / WANDERINGMINDS
Grant ID : 646927
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : “Prospective Psychology Stage 2: A Research Competition”
Funding organization : John Templeton Foundation
Project name : Wandering Minds: Interdisciplinary Experiments on Self-Generated Thought
Grant ID : 89440 ; 89439
Funding program : -
Funding organization : Volkswagen Foundation

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 146 Sequence Number: - Start / End Page: 804 - 813 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166