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  A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., et al. (2017). A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), 10-15. doi:10.1038/nn.4425.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-0EE2-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-1F01-0
Genre: Journal Article
Other : A neuronal PI(3,4,5)P(3)-dependent program of oligodendrocyte precursor recruitment and myelination

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 Creators:
Goebbels, Sandra1, Author           
Wieser, Georg L.1, Author           
Pieper, Alexander2, Author           
Spitzer, Sonia, Author
Weege, Bettina2, Author           
Yan, Kuo, Author
Edgar, Julia M.2, Author           
Yagensky, Oleksandr2, Author           
Wichert, Sven P.2, Author           
Agarwal, Amit2, Author           
Karram, Khalad, Author
Renier, Nicolas, Author
Tessier-Lavigne, Marc, Author
Rossner, Moritz J.2, Author           
Káradóttir, Ragnhildur Thóra, Author
Nave, Klaus-Armin2, Author           
Affiliations:
1Developmental neurobiology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173665              
2Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              

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 Abstract: The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1–mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination.

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Language(s): eng - English
 Dates: 2016-09-262016-10-242017-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nn.4425
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 10 - 15 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931