English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Drosophila melanogaster as a model of muscle degeneration disorders.

Kreipke, R. E., Kwon, Y. V., Shcherbata, H. R., & Ruohola-Baker, H. (2017). Drosophila melanogaster as a model of muscle degeneration disorders. In L. Pick (Ed.), Fly models of human diseases. (pp. 83-109). Cambridge, Mass.: Elsevier/Academic Pr. doi:10.1016/bs.ctdb.2016.07.003.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-AE93-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2E55-D
Genre: Book Chapter

Files

show Files
hide Files
:
2354954.pdf (Publisher version), 11MB
 
File Permalink:
-
Name:
2354954.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Kreipke, R. E., Author
Kwon, Y. V., Author
Shcherbata, H. R.1, Author              
Ruohola-Baker, H., Author
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              

Content

show
hide
Free keywords: Muscle wasting; Cachexia; Muscle degeneration; Muscular dystrophy; Motor neuron diseases
 Abstract: Drosophila melanogaster provides a powerful platform with which researchers can dissect complex genetic questions and biochemical pathways relevant to a vast array of human diseases and disorders. Of particular interest, much work has been done with flies to elucidate the molecular mechanisms underlying muscle degeneration diseases. The fly is particularly useful for modeling muscle degeneration disorders because there are no identified satellite muscle cells to repair adult muscle following injury. This allows for the identification of endogenous processes of muscle degeneration as discrete events, distinguishable from phenotypes due to the lack of stem cell-based regeneration. In this review, we will discuss the ways in which the fruit fly provides a powerful platform with which to study human muscle degeneration disorders.

Details

show
hide
Language(s): eng - English
 Dates: 2016-08-052017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/bs.ctdb.2016.07.003
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Fly models of human diseases.
Source Genre: Book
 Creator(s):
Pick, L., Editor
Affiliations:
-
Publ. Info: Cambridge, Mass. : Elsevier/Academic Pr.
Pages: XIX, 433 Volume / Issue: - Sequence Number: - Start / End Page: 83 - 109 Identifier: ISBN: 978-0-12-802904-6

Source 2

show
hide
Title: Current topics in developmental biology
Source Genre: Series
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 121 Sequence Number: - Start / End Page: - Identifier: -