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  Cortex is driven by weak but synchronously active thalamocortical synapses

Bruno, R. M., & Sakmann, B. (2006). Cortex is driven by weak but synchronously active thalamocortical synapses. Science, 312(5780), 1622-1627. doi:10.1126/science.1124593.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B0BB-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B0BC-7
Genre: Journal Article
Alternative Title : Cortex is driven by weak but synchronously active thalamocortical synapses

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Science_312_2006_1622.pdf (Any fulltext), 419KB
 
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 Creators:
Bruno, Randy M.1, Author              
Sakmann, Bert1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Sensory stimuli reach the brain via the thalamocortical projection, a group of axons thought to be among the most powerful in the neocortex. Surprisingly, these axons account for only approximately 15% of synapses onto cortical neurons. The thalamocortical pathway might thus achieve its effectiveness via high-efficacy thalamocortical synapses or via amplification within cortical layer 4. In rat somatosensory cortex, we measured in vivo the excitatory postsynaptic potential evoked by a single synaptic connection and found that thalamocortical synapses have low efficacy. Convergent inputs, however, are both numerous and synchronous, and intracortical amplification is not required. Our results suggest a mechanism of cortical activation by which thalamic input alone can drive cortex.

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Language(s): eng - English
 Dates: 2006-01-042006-05-052006-06-16
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665283
DOI: 10.1126/science.1124593
URI: https://www.ncbi.nlm.nih.gov/pubmed/16778049
Other: 6773
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 312 (5780) Sequence Number: - Start / End Page: 1622 - 1627 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1