English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Molecular Force Sensors: From Fundamental Concepts toward Applications in Cell Biology

Göktas, M., & Blank, K. G. (2017). Molecular Force Sensors: From Fundamental Concepts toward Applications in Cell Biology. Advanced Materials Interfaces, 4(1): 1600441. doi:10.1002/admi.201600441.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BCEE-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9C96-2
Genre: Journal Article

Files

show Files
hide Files
:
2357816.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
2357816.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Accepted Manuscript.pdf (Any fulltext), 3MB
Name:
Accepted Manuscript.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Göktas, Melis1, Author              
Blank, Kerstin G.1, Author              
Affiliations:
1Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2301698              

Content

show
hide
Free keywords: extracellular matrix, focal adhesions, mechanosensing, mechanotransduction, molecular force sensors
 Abstract: Mechanical signals are central for the regulation of developmental, physiological, and pathological processes within biological systems. Force transduction across the cell–extracellular matrix (ECM) interface is highly crucial for regulating cell fate via mechanosensing and mechanotransduction cascades. The key molecules involved in these highly sophisticated processes have been identified in recent years. But little is still known about their interactions and in particular the molecular forces that determine these interactions. This is due to the limited availability of techniques that allow for investigating force propagation and mechanobiochemical signal conversion at the molecular level in live cells. In this progress report, currently available tools for measuring the molecular forces involved in cellular mechanosensing and mechanotransduction are summarized, specifically highlighting recent advances in the development of molecular force sensors (MFSs). MFSs convert the applied force into a fluorescence signal, allowing for a direct readout of tension with optical microscopy techniques. Moving from molecular design principles to applications of MFSs, important results are summarized, highlighting the new mechanistic information that has been obtained about mechanobiochemical processes at the cell–ECM interface. This progress report finishes with a critical discussion of current promises and limitations, providing perspectives for future research in this quickly evolving field.

Details

show
hide
Language(s):
 Dates: 2016-11-022017-01-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/admi.201600441
Other: AM am 20.1. erbeten
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Materials Interfaces
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 4 (1) Sequence Number: 1600441 Start / End Page: - Identifier: ISSN: 2196-7350