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  Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene.

Chowdhury, K., Dietrich, S., Balling, R., Guenet, J. L., & Gruss, P. (1989). Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Nucleic Acids Research, 17(224), 10427-10438. doi:10.1093/nar/17.24.10427.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B76B-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B76C-1
Genre: Journal Article

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Chowdhury, K.1, Author              
Dietrich, S., Author
Balling, R., Author
Guenet, J. L., Author
Gruss, P.2, Author              
Affiliations:
1Facility of Microarray Analyses, MPI for biophysical chemistry, Max Planck Society, ou_578589              
2Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

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 Abstract: Zinc finger proteins (Zfp) are encoded by a large family of genes present in many organisms including yeast and human. Some of them are transcriptional activators and bind specifically to DNA by zinc mediated folded structures commonly known as zinc fingers. The Drosophila Krūppel (Kr) is a segmentation gene and encodes a zinc finger protein. Using a probe from the finger domain of Kr, we have isolated a structurally related gene Zfp-1 from the mouse. In this paper, we report the complete nucleotide sequence of two cDNA clones and the amino acid sequence deduced from them. The putative Zfp-1 protein contains in addition to 7 zinc fingers, two helix-turn-helix motifs. During murine embryogenesis, the Zfp-1 was found to express at a peak level in day 12 embryos. The ubiquitously expressed Zfp-1 gene is located in the 16q region on mouse chromosome 8, between the uvomorulin and the tyrosine amino transferase genes.

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Language(s): eng - English
 Dates: 1989-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/nar/17.24.10427
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Title: Nucleic Acids Research
Source Genre: Journal
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Pages: - Volume / Issue: 17 (224) Sequence Number: - Start / End Page: 10427 - 10438 Identifier: -