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  Why calcium? How calcium became the best communicator.

Carafoli, E., & Krebs, J. (2016). Why calcium? How calcium became the best communicator. Journal of Biological Chemistry, 291(40), 20849-20857. doi:10.1074/jbc.R116.735894.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-B854-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-9EC2-B
Genre: Journal Article

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2358816.pdf (Publisher version), 2MB
 
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 Creators:
Carafoli, E., Author
Krebs, J.1, Author              
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1Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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 Abstract: Calcium carries messages to virtually all important functions of cells. Although it was already active in unicellular organisms, its role became universally important after the transition to multicellular life. In this Minireview, we explore how calcium ended up in this privileged position. Most likely its unique coordination chemistry was a decisive factor as it makes its binding by complex molecules particularly easy even in the presence of large excesses of other cations, e.g. magnesium. Its free concentration within cells can thus be maintained at the very low levels demanded by the signaling function. A large cadre of proteins has evolved to bind or transport calcium. They all contribute to buffer it within cells, but a number of them also decode its message for the benefit of the target. The most important of these “calcium sensors” are the EF-hand proteins. Calcium is an ambivalent messenger. Although essential to the correct functioning of cell processes, if not carefully controlled spatially and temporally within cells, it generates variously severe cell dysfunctions, and even cell death.

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Language(s): eng - English
 Dates: 2016-07-262016-09-30
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1074/jbc.R116.735894
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Title: Journal of Biological Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 291 (40) Sequence Number: - Start / End Page: 20849 - 20857 Identifier: -