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  TfAP-2 is required for night sleep in Drosophila.

Kucherenko, M. M., Ilangovan, V., Herzig, A., Shcherbata, H. R., & Bringmann, H. (2016). TfAP-2 is required for night sleep in Drosophila. BMC Neuroscience, 17: 72. doi:10.1186/s12868-016-0306-3.

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Kucherenko, M. M.1, Autor           
Ilangovan, V.2, Autor           
Herzig, A.3, Autor           
Shcherbata, H. R.1, Autor           
Bringmann, H.4, Autor           
Affiliations:
1Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society, ou_578608              
2Department of Genes and Behavior, MPI for Biophysical Chemistry, Max Planck Society, ou_persistent34              
3Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
4Research Group of Sleep and Waking, MPI for biophysical chemistry, Max Planck Society, ou_578607              

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Schlagwörter: Drosophila, AP-2, Char syndrome, Insomnia, C. elegans
 Zusammenfassung: BACKGROUND: The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been linked to sleep disorders. These data suggest that AP-2 transcription factors may be highly conserved regulators of various types of sleep behavior. Here, we tested the idea that AP-2 controls adult sleep in Drosophila. RESULTS: Drosophila has one AP-2 ortholog called TfAP-2, which is essential for viability. To investigate its potential role in sleep behavior and neural development, we specifically downregulated TfAP-2 in the nervous system. We found that neuronal TfAP-2 knockdown almost completely abolished night sleep but did not affect day sleep. TfAP-2 insufficiency affected nervous system development. Conditional TfAP-2 knockdown in the adult also produced a modest sleep phenotype, suggesting that TfAP-2 acts both in larval as well as in differentiated neurons. CONCLUSIONS: Thus, our results show that AP-2 transcription factors are highly conserved regulators of development and sleep.

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Sprache(n): eng - English
 Datum: 2016-11-09
 Publikationsstatus: Online veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1186/s12868-016-0306-3
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Titel: BMC Neuroscience
Genre der Quelle: Zeitschrift
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Seiten: 11 Band / Heft: 17 Artikelnummer: 72 Start- / Endseite: - Identifikator: -