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  Development of the intrinsic language network in preschool children from ages 3 to 5 years

Xiao, Y., Brauer, J., Lauckner, M., Zhai, H., Jia, F., Margulies, D. S., et al. (2016). Development of the intrinsic language network in preschool children from ages 3 to 5 years. PLoS One, 11(11): e0165802. doi:10.1371/journal.pone.0165802.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BA96-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1E75-9
Genre: Journal Article

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 Creators:
Xiao, Yaqiong1, Author              
Brauer, Jens1, Author              
Lauckner, Mark, Author
Zhai, Hongchang, Author
Jia, Fucang, Author
Margulies, Daniel S.2, Author              
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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 Abstract: Resting state studies of spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal have shown great potential in mapping the intrinsic functional connectivity of the human brain underlying cognitive functions. The aim of the present study was to explore the developmental changes in functional networks of the developing human brain exemplified with the language network in typically developing preschool children. To this end, resting-sate fMRI data were obtained from native Chinese children at ages of 3 and 5 years, 15 in each age group. Resting-state functional connectivity (RSFC) was analyzed for four regions of interest; these are the left and right anterior superior temporal gyrus (aSTG), left posterior superior temporal gyrus (pSTG), and left inferior frontal gyrus (IFG). The comparison of these RSFC maps between 3- and 5-year-olds revealed that RSFC decreases in the right aSTG and increases in the left hemisphere between aSTG seed and IFG, between pSTG seed and IFG, as well as between IFG seed and posterior superior temporal sulcus. In a subsequent analysis, functional asymmetry of the language network seeding in aSTG, pSTG and IFG was further investigated. The results showed an increase of left lateralization in both RSFC of pSTG and of IFG from ages 3 to 5 years. The IFG showed a leftward lateralized trend in 3-year-olds, while pSTG demonstrated rightward asymmetry in 5-year-olds. These findings suggest clear developmental trajectories of the language network between 3- and 5-year-olds revealed as a function of age, characterized by increasing long-range connections and dynamic hemispheric lateralization with age. Our study provides new insights into the developmental changes of a well-established functional network in young children and also offers a basis for future cross-culture and cross-age studies of the resting-state language network.

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Language(s): eng - English
 Dates: 2016-04-202016-10-182016-11-03
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0165802
PMID: 27812160
PMC: PMC5094780
Other: eCollection 2016
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 11 (11) Sequence Number: e0165802 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850