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  Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

Komai, S., Licznerski, P., Cetin, A., Waters, D. J., Denk, W., Brecht, M., et al. (2006). Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nature Neuroscience, 9(9), 1125-1133. doi:10.1038/nn1752.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BB23-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BB24-7
Genre: Journal Article
Alternative Title : Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

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 Creators:
Komai, Shoji1, Author              
Licznerski, Pawel2, Author              
Cetin, Ali2, Author              
Waters, David Jack3, Author              
Denk, Winfried1, Author              
Brecht, Michael3, Author              
Osten, Pavel2, Author              
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Sensory experience is necessary for normal cortical development. This has been shown by sensory deprivation and pharmacological perturbation of the cortex. Because these manipulations affect the cortical network as a whole, the role of postsynaptic cellular properties during experience-dependent development is unclear. Here we addressed the developmental role of somatodendritic excitability, which enables postsynaptic spike timing-dependent forms of plasticity, in rat somatosensory cortex. We used short interfering RNA (siRNA)-based knockdown of Na+ channels to suppress the somatodendritic excitability of small numbers of layer 2/3 pyramidal neurons in the barrel cortex, without altering the ascending sensory pathway. In vivo recordings from siRNA-expressing cells revealed that this manipulation interfered with the normal developmental strengthening of sensory responses. The sensory responsiveness of neighboring cortical neurons was unchanged, indicating that the cortical network was unchanged. We conclude that somatodendritic excitability of the postsynaptic neuron is needed for the regulation of synaptic strength in the developing sensory cortex.

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Language(s): eng - English
 Dates: 2006-04-032006-07-272006-08-202006-09-01
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665388
DOI: 10.1038/nn1752
URI: http://www.ncbi.nlm.nih.gov/pubmed/16921372
Other: 6652
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 9 (9) Sequence Number: - Start / End Page: 1125 - 1133 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931