English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Complex carbohydrate recognition by proteins: Fundamental insights from bacteriophage cell adhesion systems

Broeker, N. K., Andres, D., Kang, Y., Gohlke, U., Schmidt, A., Kunstmann, S., et al. (2017). Complex carbohydrate recognition by proteins: Fundamental insights from bacteriophage cell adhesion systems. Perspectives in Science, 11, 45-52. doi:10.1016/j.pisc.2016.10.001.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BE83-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-8A8E-3
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 2MB
Name:
Article.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Broeker, Nina K., Author
Andres, Dorothee, Author
Kang, Yu1, Author              
Gohlke, Ulrich, Author
Schmidt, Andreas, Author
Kunstmann, Sonja, Author
Santer, Mark1, Author              
Barbirz, Stefanie, Author
Affiliations:
1Mark Santer, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863326              

Content

show
hide
Free keywords: structural thermodynamics; tailspike protein; carbohydrate interaction; polysaccharide dynamics; bacterial O-antigen; Open Access
 Abstract: Protein–glycan interactions are ubiquitous in nature. Molecular description of complex formation and the underlying thermodynamics, however, are not well understood due to the lack of model systems. Bacteriophage tailspike proteins (TSP) possess binding sites for bacterial cell surfaces oligosaccharides. In this article we describe the analysis of TSP-oligosaccharide complexes. TSP provide large glycan interaction sites where affinity and specificity are guided by the protein surface solvation and the conformational space sampled by the respective glycan. Furthermore, we describe a computational approach to analyze the conformational space sampled by flexible glycans of bacterial origin, a prerequisite for a thorough understanding of TSP-oligosaccharide interactions.

Details

show
hide
Language(s):
 Dates: 2016-11-102017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.pisc.2016.10.001
BibTex Citekey: Broeker2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Perspectives in Science
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam [u.a.] : Elsevier
Pages: - Volume / Issue: 11 Sequence Number: - Start / End Page: 45 - 52 Identifier: ISSN: 2213-0209