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  Background synaptic activity is sparse in neocortex

Waters, D. J., & Helmchen, F. (2006). Background synaptic activity is sparse in neocortex. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 26(32), 8267-8277. doi:10.1523/JNEUROSCI.2152-06.2006.

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Genre: Journal Article
Alternative Title : Background synaptic activity is sparse in neocortex

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JNeurosci_26_2006_8267.pdf (Any fulltext), 496KB
 
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 Creators:
Waters, David Jack1, Author           
Helmchen, Fritjof1, Author           
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: pyramidal cell; summation; patch clamp; dendrite; synaptic integration; dendrite
 Abstract: Neurons are continually exposed to background synaptic activity in vivo. This is thought to influence neural information processing, but background levels of excitation and inhibition remain controversial. Here we show, using whole-cell recordings in anesthetized rats, that spontaneous depolarizations ("Up states") in neocortical pyramidal neurons are driven by sparse, mostly excitatory synaptic activity (less than five inputs per millisecond; approximately 10% inhibitory). The mean synaptic conductance change is small (<10 nS at the soma) and opposed by anomalous rectification, resulting in a net increase in input resistance during Up states. These conditions enhance the effectiveness of each synapse at depolarized potentials. Hence, neocortical networks are relatively quiet at rest, and the effect of synaptic background is weaker than previously thought.

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Language(s): eng - English
 Dates: 2006-05-212006-07-032006-08-09
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665401
DOI: 10.1523/JNEUROSCI.2152-06.2006
URI: http://www.ncbi.nlm.nih.gov/pubmed/16899721
Other: 6636
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 26 (32) Sequence Number: - Start / End Page: 8267 - 8277 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1