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  The contribution of single synapses to sensory representation in vivo

Arenz, A., Silver, R. A., Schaefer, A. T., & Margrie, T. W. (2008). The contribution of single synapses to sensory representation in vivo. Science, 321(5891), 977-980. doi:10.1126/science.1158391.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-BEC3-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DB86-2
Genre: Journal Article

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 Creators:
Arenz, Alexander, Author
Silver, R. Angus, Author
Schaefer, Andreas T.1, Author              
Margrie, Troy W.1, 2, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The extent to which synaptic activity can signal a sensory stimulus limits the information available to a neuron. We determined the contribution of individual synapses to sensory representation by recording excitatory postsynaptic currents (EPSCs) in cerebellar granule cells during a time-varying, quantifiable vestibular stimulus. Vestibular-sensitive synapses faithfully reported direction and velocity, rather than position or acceleration of whole-body motion, via bidirectional modulation of EPSC frequency. The lack of short-term synaptic dynamics ensured a highly linear relationship between velocity and charge transfer, and as few as 100 synapses provided resolution approaching psychophysical limits. This indicates that highly accurate stimulus representation can be achieved by small networks and even within single neurons.

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Language(s): eng - English
 Dates: 2008-03-282008-07-082008-08-15
 Publication Status: Published in print
 Pages: 5
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 Rev. Method: Peer
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 321 (5891) Sequence Number: - Start / End Page: 977 - 980 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1