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  Antibodies for prevention and treatment of diseases caused by Clostridium difficile

Seeberger, P. H., Martin, C. E., Bröcker, F., & Chakkumkal, A.(2016). Antibodies for prevention and treatment of diseases caused by Clostridium difficile.

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 Creators:
Seeberger, Peter H.1, Author              
Martin, Christopher E.1, Author              
Bröcker, Felix2, Author              
Chakkumkal, Anish2, Author              
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
2Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              

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 Abstract: The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the Clostridium difficile glycopolymer PS-I: α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by C. difficile. The present invention further pertains to a method of treating or preventing a disease caused by the pathogen Clostridium difficile, which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.

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 Dates: 2015-12-102016-05-19
 Publication Status: Published online
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 Identifiers: Patent Publication Nr.: US20160137724 A1
Patent Application Nr.: US201514964763
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