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Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_2364357_5
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Antibodies for prevention and treatment of diseases caused by Clostridium difficile
Antibodies for prevention and treatment of diseases caused by Clostridium difficile
.
(2016).
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https://hdl.handle.net/11858/00-001M-0000-002C-0391-E
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https://hdl.handle.net/11858/00-001M-0000-002C-0392-C
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Patent
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2364357.pdf (Publisher version), 3MB
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2364357.pdf
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Creators
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Seeberger, Peter H.
1
, Inventor
Martin, Christopher E.
2
, Inventor
Bröcker, Felix
3
, Inventor
Chakkumkal, Anish
3
, Inventor
Affiliations
:
1
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285
2
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308
3
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299
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Abstract
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The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the Clostridium difficile glycopolymer PS-I: α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by C. difficile. The present invention further pertains to a method of treating or preventing a disease caused by the pathogen Clostridium difficile, which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.
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Submitted:
2015-12-10
Published Online:
2016-05-19
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Published online
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Patent Publication Nr.: US20160137724 A1
Patent Application Nr.: US201514964763
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