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  Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns

Broser, P. J., Grinevich, V., Osten, P., Sakmann, B., & Haydon-Wallace, D. J. (2008). Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns. Cerebral Cortex, 18(7), 1588-1603. doi:10.1093/cercor/bhm189.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-00F0-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DBC1-F
Genre: Journal Article

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 Creators:
Broser, Philip Julian1, Author              
Grinevich, Valery2, Author              
Osten, Pavel2, Author              
Sakmann, Bert1, Author              
Haydon-Wallace, Damian J.1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: axon anatomy; barrel cortex; extended focus imaging bright field microscopy; lentivirus; whisker
 Abstract: We examined the effect of whisker trimming during early postnatal development on the morphology of axonal arbors in rat somatosensory cortex. Axonal arbors from populations of layer 2/3 pyramidal neurons in the D2 column were labeled by lentivirus-mediated expression of green fluorescent protein. Axonal projection patterns were compared between untrimmed control animals and animals with all whiskers in A-, B-, and C-rows trimmed (D- and E-rows left intact) from postnatal days 7 to 15 (termed from here on DE-pairing). Control animals had approximately symmetrical horizontal projections toward C- and E-row columns in both supra- and infragranular layers. Following DE-pairing, the density of axons in supragranular layers projecting from the labeled neurons in the D2 column was higher in E- than in C-row columns. This asymmetry resulted primarily from a reduction in projection density toward the deprived C-row columns. In contrast, no change was observed in infragranular layers. The results indicate that DE-pairing during early postnatal development results in reduced axonal projection from nondeprived into deprived columns and that cortical neurons are capable of structural rearrangements at subsets of their axonal arbors.

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Language(s): eng - English
 Dates: 2007-11-122008-07
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 18 (7) Sequence Number: - Start / End Page: 1588 - 1603 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440