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  Imaging in vivo: watching the brain in action

Denk, W., & Kerr, J. (2008). Imaging in vivo: watching the brain in action. Nature Reviews Neuroscience, 9(3), 195-205. doi:10.1038/nrn2338.

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Denk, Winfried1, Author           
Kerr, Jason1, Author           
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: The appeal of in vivo cellular imaging to any neuroscientist is not hard to understand: it is almost impossible to isolate individual neurons while keeping them and their complex interactions with surrounding tissue intact. These interactions lead to the complex network dynamics that underlie neural computation which, in turn, forms the basis of cognition, perception and consciousness. In vivo imaging allows the study of both form and function in reasonably intact preparations, often with subcellular spatial resolution, a time resolution of milliseconds and a purview of months. Recently, the limits of what can be achieved in vivo have been pushed into terrain that was previously only accessible in vitro, due to advances in both physical-imaging technology and the design of molecular contrast agents.

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Language(s): eng - English
 Dates: 2008-02-132008-02-132008-03-01
 Publication Status: Published in print
 Pages: 11
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 Rev. Type: Peer
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Title: Nature Reviews Neuroscience
Source Genre: Journal
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Publ. Info: England : Nature Pub. Group
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 195 - 205 Identifier: ISSN: 1471-003X
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000937