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  Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex

Frick, A., Feldmeyer, D., Helmstaedter, M., & Sakmann, B. (2008). Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex. Cerebral Cortex, 18(2), 397-406. doi:10.1093/cercor/bhm074.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-040E-E Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DBE0-C
Genre: Journal Article

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 Creators:
Frick, Andreas1, Author              
Feldmeyer, Dirk1, Author              
Helmstaedter, Moritz1, 2, Author              
Sakmann, Bert1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497699              

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Free keywords: barrel cortex; cortical connectivity; layer 5A; short-term dynamics; synaptic transmission
 Abstract: Layer 5 (L5) of somatosensory cortex is a major gateway for projections to intra- and subcortical brain regions. This layer is further divided into 5A and 5B characterized by relatively separate afferent and efferent connections. Little is known about the organization of connections within L5A of neocortical columns. We therefore used paired recordings to probe the anatomy and physiology of monosynaptic connections between L5A pyramidal neurons within the barrel columns of somatosensory cortex in acute slices of approximately 3-week-old rats. Post hoc reconstruction and calculation of the axodendritic overlap of pre- and postsynaptic neurons, together with identification of putative synaptic contacts (3.5 per connection), indicated a preferred innervation domain in the proximal dendritic region. Synaptic transmission was reliable (failure rate <2%) and had a low variability (coefficient of variation of 0.3). Unitary excitatory postsynaptic potential (EPSP) amplitudes varied 30-fold with a mean of 1.2 mV and displayed depression over a wide range of frequencies (2-100 Hz) during bursts of presynaptic firing. A single L5A pyramidal neuron was estimated to target approximately 270 other pyramidal neurons within the same layer of its home barrel column, suggesting a mechanism of feed-forward excitation by which synchronized single action potentials are efficiently transmitted within L5A of juvenile cortex.

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Language(s): eng - English
 Dates: 2007-06-042008-02-01
 Publication Status: Published in print
 Pages: 10
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 Table of Contents: -
 Rev. Method: Peer
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 18 (2) Sequence Number: - Start / End Page: 397 - 406 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440