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  Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex

Helmstaedter, M., Staiger, J. F., Sakmann, B., & Feldmeyer, D. (2008). Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 28(33), 8273-8284. doi:10.1523/JNEUROSCI.5701-07.2008.

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 Urheber:
Helmstaedter, Moritz1, 2, Autor           
Staiger, Jochen F., Autor
Sakmann, Bert2, Autor           
Feldmeyer, Dirk2, Autor           
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Schlagwörter: barrel cortex; connectivity; GABAergic interneurons; layer 2/3; synaptic connection; target cell specificity
 Zusammenfassung: Interneurons in layers 2/3 are excited by pyramidal cells within the same layer (Reyes et al., 1998; Gupta et al., 2000), but little is known about translaminar innervation of these interneurons by spiny neurons in the main cortical input layer 4 (L4). Here, we investigated (1) how efficiently L4 spiny neurons excite L2/3 interneurons via monosynaptic connections, (2) whether glutamate release from axon terminals of L4 spiny neurons depends on the identity of the postsynaptic interneuron, and (3) how L4-to-L2/3 interneuron connections compare with L4-to-L2/3 pyramidal neuron connections. We recorded from pairs of L4 spiny neurons and L2/3 interneurons in acute slices of rat barrel cortex of postnatal day 20 (P20) to P29 rats. The L4-to-L2/3 interneuron connections had an average unitary EPSP of 1.2 +/- 1.1 mV. We found an average of 2.3 +/- 0.8 contacts per connection, and the L4-to-L2/3 interneuron innervation domains were mostly column restricted. Unitary EPSP amplitudes and paired-pulse ratios in the L4-to-L2/3 interneuron connections depended on the "group" of the postsynaptic interneuron. Averaged over all L4-to-L2/3 interneuron connections, unitary EPSP amplitudes were 1.8-fold higher than in the translaminar L4-to-L2/3 pyramidal cell connections. Our results suggest that L4 spiny neurons may more efficiently recruit L2/3 interneurons than L2/3 pyramidal neurons, and that glutamate release from translaminar boutons of L4 spiny neuron axons is target cell specific.

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Sprache(n): eng - English
 Datum: 2008-05-262007-12-222008-06-192008-08-13
 Publikationsstatus: Erschienen
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
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Titel: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Andere : J. Neurosci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Baltimore, MD : The Society
Seiten: - Band / Heft: 28 (33) Artikelnummer: - Start- / Endseite: 8273 - 8284 Identifikator: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1