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  Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex

Helmstaedter, M., Staiger, J. F., Sakmann, B., & Feldmeyer, D. (2008). Efficient recruitment of layer 2/3 interneurons by layer 4 input in single columns of rat somatosensory cortex. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 28(33), 8273-8284. doi:10.1523/JNEUROSCI.5701-07.2008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0606-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DBEC-0
Genre: Journal Article

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JNeurosci_28_2008_8273.pdf (Any fulltext), 19MB
 
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 Creators:
Helmstaedter, Moritz1, 2, Author              
Staiger, Jochen F., Author
Sakmann, Bert2, Author              
Feldmeyer, Dirk2, Author              
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: barrel cortex; connectivity; GABAergic interneurons; layer 2/3; synaptic connection; target cell specificity
 Abstract: Interneurons in layers 2/3 are excited by pyramidal cells within the same layer (Reyes et al., 1998; Gupta et al., 2000), but little is known about translaminar innervation of these interneurons by spiny neurons in the main cortical input layer 4 (L4). Here, we investigated (1) how efficiently L4 spiny neurons excite L2/3 interneurons via monosynaptic connections, (2) whether glutamate release from axon terminals of L4 spiny neurons depends on the identity of the postsynaptic interneuron, and (3) how L4-to-L2/3 interneuron connections compare with L4-to-L2/3 pyramidal neuron connections. We recorded from pairs of L4 spiny neurons and L2/3 interneurons in acute slices of rat barrel cortex of postnatal day 20 (P20) to P29 rats. The L4-to-L2/3 interneuron connections had an average unitary EPSP of 1.2 +/- 1.1 mV. We found an average of 2.3 +/- 0.8 contacts per connection, and the L4-to-L2/3 interneuron innervation domains were mostly column restricted. Unitary EPSP amplitudes and paired-pulse ratios in the L4-to-L2/3 interneuron connections depended on the "group" of the postsynaptic interneuron. Averaged over all L4-to-L2/3 interneuron connections, unitary EPSP amplitudes were 1.8-fold higher than in the translaminar L4-to-L2/3 pyramidal cell connections. Our results suggest that L4 spiny neurons may more efficiently recruit L2/3 interneurons than L2/3 pyramidal neurons, and that glutamate release from translaminar boutons of L4 spiny neuron axons is target cell specific.

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Language(s): eng - English
 Dates: 2008-05-262007-12-222008-06-192008-08-13
 Publication Status: Published in print
 Pages: 12
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 Table of Contents: -
 Rev. Type: Peer
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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 28 (33) Sequence Number: - Start / End Page: 8273 - 8284 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1