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  Should tissue structure suppress or amplify selection to minimize cancer risk?

Hindersin, L., Werner, B., Dingli, D., & Traulsen, A. (2016). Should tissue structure suppress or amplify selection to minimize cancer risk? Biology Direct, 11(41). doi:10.1186/s13062-016-0140-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0731-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0732-4
Genre: Journal Article

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art%253A10.1186%252Fs13062-016-0140-7.pdf_originUrl=http%3A%2F%2Fbiologydirect.biomedcentral.com%2Farticle%2F10.1186%2Fs13062-016-0140-7&token2=exp=1479907526~acl=%2Fstatic%2Fpdf%2F350%2Fart%25253A10.1186%25252Fs13062-016-0140-7.pdf_~hmac=394680e1baca3eb1adf053609ef55b6a67a6fad7c0b43dde33669b86d5f1c44e (Publisher version), 820KB
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art%253A10.1186%252Fs13062-016-0140-7.pdf?originUrl=http%3A%2F%2Fbiologydirect.biomedcentral.com%2Farticle%2F10.1186%2Fs13062-016-0140-7&token2=exp=1479907526~acl=%2Fstatic%2Fpdf%2F350%2Fart%25253A10.1186%25252Fs13062-016-0140-7.pdf*~hmac=394680e1baca3eb1adf053609ef55b6a67a6fad7c0b43dde33669b86d5f1c44e
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 Creators:
Hindersin, Laura1, Author              
Werner, Benjamin, Author              
Dingli, David, Author
Traulsen, Arne1, Author              
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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 Abstract: It has been frequently argued that tissues evolved to suppress the accumulation of growth enhancing cancer inducing mutations. A prominent example is the hierarchical structure of tissues with high cell turnover, where a small number of tissue specific stem cells produces a large number of specialized progeny during multiple differentiation steps. Another well known mechanism is the spatial organization of stem cell populations and it is thought that this organization suppresses fitness enhancing mutations. However, in small populations the suppression of advantageous mutations typically also implies an increased accumulation of deleterious mutations. Thus, it becomes an important question whether the suppression of potentially few advantageous mutations outweighs the combined effects of many deleterious mutations.

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Language(s): eng - English
 Dates: 2016-02-242016-06-042016-08-232016
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1186/s13062-016-0140-7
BibTex Citekey: Hindersin2016
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Title: Biology Direct
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 11 (41) Sequence Number: - Start / End Page: - Identifier: Other: 1745-6150
Other: 1745-6150
CoNE: /journals/resource/1745-6150