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  Improved models for animal research

Sprengel, R., Eshkind, L., Hengstler, J. G., & Bockamp, E. (2008). Improved models for animal research. In P. M. Conn (Ed.), Sourcebook of models for biomedical research (pp. 17-24). Totowa, NJ: Humana Press.

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SourcebookModBiomedRes_2008_17.pdf (Any fulltext), 6MB
 
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 Creators:
Sprengel, Rolf1, Author              
Eshkind, L., Author
Hengstler, Jan G., Author
Bockamp, Ernesto, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Transgenic mice / Knockout mice / Conditional mouse models / Cre and Flp recombinase / Tetracycline system / RNAi / Knockdown mice / Functional genomics
 Abstract: Experimental animal models are critical to understand gene function and human disease. Many rodent models are presently available providing avenues to elucidate gene function and/or to recapitulate specific pathological conditions. To a large extent, successful translation of clinical evidence or analytical data into appropriate mouse models is possible through progress in transgenic or gene deletion technology. Despite these significant improvements, major limitations still exist in manipulating the mouse genome. For this reason and to maximize success, the design and planning of mouse models need good knowledge concerning the requirements and limitations of commonly used strategies and emerging technologies. The purpose of this chapter is to provide a current overview of strategies for manipulating the mouse genome.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/978-1-59745-285-4_3
 Degree: -

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Title: Sourcebook of models for biomedical research
Source Genre: Book
 Creator(s):
Conn, P. Michael, Author
Conn, P. Michael, Editor
Affiliations:
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Publ. Info: Totowa, NJ : Humana Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 17 - 24 Identifier: ISBN: 978-1-58829-933-8