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  Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfctory bulb

Tabor, R., & Friedrich, R. W. (2008). Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfctory bulb. PLoS One, 3(1): 1416, pp. 1-17. doi:10.1371/journal.pone.0001416.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-09F8-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DE4C-2
Genre: Journal Article

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 Creators:
Tabor, Rico1, Author              
Friedrich, Rainer W.1, Author              
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: Although synaptic functions of ionotropic glutamate receptors in the olfactory bulb have been studied in vitro, their roles in pattern processing in the intact system remain controversial. We therefore examined the functions of ionotropic glutamate receptors during odor processing in the intact olfactory bulb of zebrafish using pharmacological manipulations. Odor responses of mitral cells and interneurons were recorded by electrophysiology and 2-photon Ca(2+) imaging. The combined blockade of AMPA/kainate and NMDA receptors abolished odor-evoked excitation of mitral cells. The blockade of AMPA/kainate receptors alone, in contrast, increased the mean response of mitral cells and decreased the mean response of interneurons. The blockade of NMDA receptors caused little or no change in the mean responses of mitral cells and interneurons. However, antagonists of both receptor types had diverse effects on the magnitude and time course of individual mitral cell and interneuron responses and, thus, changed spatio-temporal activity patterns across neuronal populations. Oscillatory synchronization was abolished or reduced by AMPA/kainate and NMDA receptor antagonists, respectively. These results indicate that (1) interneuron responses depend mainly on AMPA/kainate receptor input during an odor response, (2) interactions among mitral cells and interneurons regulate the total olfactory bulb output activity, (3) AMPA/kainate receptors participate in the synchronization of odor-dependent neuronal ensembles, and (4) ionotropic glutamate receptor-containing synaptic circuits shape odor-specific patterns of olfactory bulb output activity. These mechanisms are likely to be important for the processing of odor-encoding activity patterns in the olfactory bulb.

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Language(s): eng - English
 Dates: 2007-11-132007-12-022008-01-092008-01-09
 Publication Status: Published in print
 Pages: 17
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 Table of Contents: -
 Rev. Type: Peer
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 3 (1) Sequence Number: 1416 Start / End Page: 1 - 17 Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850