English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

Wang, J., Thingholm, L. B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J. R., et al. (2016). Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48, 1396-1406. doi:10.1038/ng.3695.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0A0F-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0A10-9
Genre: Journal Article

Files

show Files
hide Files
:
Pre-Print MS version.pdf (Preprint), 8MB
 
File Permalink:
-
Name:
Pre-Print MS version.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Evolutionary Biology, Plön; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Wang, Jun1, Author              
Thingholm, Louise B, Author
Skiecevičienė, Jurgita, Author
Rausch, Philipp1, Author              
Kummen, Martin, Author
Hov, Johannes R, Author
Degenhardt, Frauke, Author
Heinsen, Femke-Anouska, Author
Rühlemann, Malte C, Author
Szymczak, Silke, Author
Holm, Kristian, Author
Esko, Tönu, Author
Sun, Jun, Author
Pricop-Jeckstadt, Mihaela, Author
Al-Dury, Samer, Author
Bohov, Pavol, Author
Bethune, Jörn, Author
Sommer, Felix, Author
Ellinghaus, David, Author
Berge, Rolf K, Author
Hübenthal, Matthias, AuthorKoch, Manja, AuthorSchwarz, Karin, AuthorRimbach, Gerald, AuthorHübbe, Patricia, AuthorPan, Wei-Hung, AuthorSheibani-Tezerji, Raheleh, AuthorHäsler, Robert, AuthorRosenstiel, Philipp, AuthorD'Amato, Mauro, AuthorCloppenborg-Schmidt, Katja, AuthorKünzel, Sven2, Author              Laudes, Matthias, AuthorMarschall, Hanns-Ulrich, AuthorLieb, Wolfgang, AuthorNöthlings, Ute, AuthorKarlsen, Tom H, AuthorBaines, John F.1, Author              Franke, Andre, Author more..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

Content

show
hide
Free keywords: Genome-wide association studies; Microbial genetics
 Abstract: Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr−/− mice relative to control mice and correlations between the microbiota and serum measurements of selected bile and fatty acids in humans, including known ligands and downstream metabolites of VDR. Genome-wide significant (P < 5 × 10−8) associations at multiple additional loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components. Non-genetic and genetic factors each account for approximately 10% of the variation in gut microbiota, whereby individual effects are relatively small.

Details

show
hide
Language(s): eng - English
 Dates: 2016-04-292016-09-152016-10-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/ng.3695
PMID: 27723756
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 48 Sequence Number: - Start / End Page: 1396 - 1406 Identifier: ISSN: 1061-4036
CoNE: /journals/resource/954925598609