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  Multiple functions of GABA(A) and GABA(B) receptors during pattern processing in the zebrafish olfactory bulb

Tabor, R., Yaksi, E., & Friedrich, R. W. (2008). Multiple functions of GABA(A) and GABA(B) receptors during pattern processing in the zebrafish olfactory bulb. European Journal of Neuroscience: European Neuroscience Association, 28(1), 117-127. doi:10.1111/j.1460-9568.2008.06316.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0A34-A Version Permalink: http://hdl.handle.net/21.11116/0000-0000-DE52-A
Genre: Journal Article

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 Creators:
Tabor, Rico1, Author              
Yaksi, Emre1, Author              
Friedrich, Rainer W.1, Author              
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: GABA, neuronal circuit, olfactory bulb, pattern processing, zebrafish
 Abstract: γ-Aminobutyric acid (GABA)ergic synapses are thought to play pivotal roles in the processing of activity patterns in the olfactory bulb (OB), but their functions have been difficult to study during odor responses in the intact system. We pharmacologically manipulated GABAA and GABAB receptors in the OB of zebrafish and analysed the effects on odor responses of the output neurons, the mitral cells (MCs), by electrophysiological recordings and temporally deconvolved two-photon Ca2+ imaging. The blockade of GABAB receptors enhanced presynaptic Ca2+ influx into afferent axon terminals, and changed the amplitude and time course of a subset of MC responses, indicating that GABAB receptors have a modulatory influence on OB output activity. The blockade of GABAA receptors induced epileptiform firing, enhanced excitatory responses and abolished fast oscillations in the local field potential. Moreover, the topological reorganization and decorrelation of MC activity patterns during the initial phase of the response was perturbed. These results indicate that GABAA receptor-containing circuits participate in the balance of excitation and inhibition, the regulation of total OB output activity, the synchronization of odor-dependent neuronal ensembles, and the reorganization of odor-encoding activity patterns. GABAA and GABAB receptors are therefore differentially involved in multiple functions of neuronal circuits in the OB.

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Language(s): eng - English
 Dates: 2008-04-112008-05-082008-07-042008-07-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 28 (1) Sequence Number: - Start / End Page: 117 - 127 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988