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  GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABAB receptors in a target-cell-specific manner

Astori, S., Luján, R., & Köhr, G. (2009). GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABAB receptors in a target-cell-specific manner. European Journal of Neuroscience: European Neuroscience Association, 30(4), 551-559. doi:10.1111/j.1460-9568.2009.06856.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0BFC-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0BFD-F
Genre: Journal Article
Alternative Title : GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABAB receptors in a target-cell-specific manner

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EurJNeurosci_30_2009_551.pdf (Any fulltext), 437KB
 
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 Creators:
Astori, Simone1, Author              
Luján, Rafael, Author
Köhr, Georg1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: baclofen, immunogold labelling, miniature current, presynaptic receptor, Purkinje cell
 Abstract: Transmitter release from boutons along a common axon is often regulated depending on the postsynaptic target. Here, GABA release from cerebellar stellate cells onto Purkinje cells and other stellate cells was examined in acute cerebellar slices of 2- and 4-week-old mice. Consistent with previous findings on action potential-dependent GABA release, we found a developmental decrease in inhibitory inputs onto Purkinje cells but not onto stellate cells when recording miniature inhibitory postsynaptic currents (mIPSCs). Although amplitudes of mIPSCs were developmentally reduced in both cell types, mIPSC frequencies were decreased in Purkinje cells but were increased in stellate cells. Similarly, modulation of GABA release by presynaptic GABAB receptors changed during development in Purkinje cells but not in stellate cells, as demonstrated by the baclofen-mediated depression of mIPSC frequency and evoked IPSC (eIPSC) amplitudes. The selectively diminished baclofen effect in 4-week-old Purkinje cells correlated with a selective downregulation of presynaptic GABAB receptors at stellate cell-to-Purkinje cell synapses observed by immunoelectron microscopy analysis. Thus, expression of GABAB receptors in stellate cell axons and presynaptic modulation of GABA release appear to change during development in a target-cell-specific manner.

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Language(s): eng - English
 Dates: 2009-02-022009-06-182009-08-072009-08
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664649
DOI: 10.1111/j.1460-9568.2009.06856.x
Other: 7502
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Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 30 (4) Sequence Number: - Start / End Page: 551 - 559 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988