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  Subcellular topography of visually driven dendritic activity in the vertebrate visual system

Bollmann, J. H., & Engert, F. (2009). Subcellular topography of visually driven dendritic activity in the vertebrate visual system. Neuron, 61(6), 895-905. doi:10.1016/j.neuron.2009.01.018.

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 Creators:
Bollmann, Johann H.1, 2, Author           
Engert, Florian, Author
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: CELLBIO; SYSNEURO; MOLNEURO
 Abstract: Neural pathways projecting from sensory organs to higher brain centers form topographic maps in which neighbor relationships are preserved from a sending to a receiving neural population. Sensory input can generate compartmentalized electrical and biochemical activity in the dendrites of a receiving neuron. Here, we show that in the developing retinotectal projection of young Xenopus tadpoles, visually driven Ca2+ signals are topographically organized at the subcellular, dendritic scale. Functional in vivo two-photon Ca2+ imaging revealed that the sensitivity of dendritic Ca2+ signals to stimulus location in visual space is correlated with their anatomical position within the dendritic tree of individual neurons. This topographic distribution was dependent on NMDAR activation, whereas global Ca2+ signals were mediated by Ca2+ influx through dendritic, voltage-dependent Ca2+ channels. These findings suggest a framework for plasticity models that invoke local dendritic Ca2+ signaling in the elaboration of neural connectivity and dendrite-specific information storage.

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Language(s): eng - English
 Dates: 20082009-01-262009-03-252009-03-26
 Publication Status: Issued
 Pages: 11
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 Table of Contents: -
 Rev. Type: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 61 (6) Sequence Number: - Start / End Page: 895 - 905 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565