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  Targeted photodynamic killing of breast cancer cells employing heptamannosylated β-cyclodextrin-mediated nanoparticle formation of an adamantane-functionalized BODIPY photosensitizer

Zhang, Q., Cai, Y., Wang, X.-J., Xu, J.-L., Ye, Z., Wang, S., et al. (2016). Targeted photodynamic killing of breast cancer cells employing heptamannosylated β-cyclodextrin-mediated nanoparticle formation of an adamantane-functionalized BODIPY photosensitizer. ACS Applied Materials and Interfaces, 8(49), 33405-33411. doi:10.1021/acsami.6b13612.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0F4A-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-612E-A
Genre: Journal Article

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 Creators:
Zhang, Quan1, Author
Cai, Ying, Author
Wang, Xiao-Jun, Author
Xu, Jia-Long, Author
Ye, Zhou1, Author              
Wang, Shengtao, Author
Seeberger, Peter H.2, Author              
Yin, Jian, Author
Affiliations:
1Peter H. Seeberger - Nanoparticles and Colloidal Polymers, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863307              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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 Abstract: The targeted delivery of a photosensitizer (PS) into specific cancer cells is an effective way to enhance the efficacy and minimize the side effects of photodynamic therapy. Herein, heptamannosylated β-cyclodextrin (β-CD) was used to mediate the formation of an adamantane (Ad)-functionalized BODIPY PS nanoparticle via strong β-CD/Ad complexation. The mannose-functionalized PS nanoparticles are selectively internalized by mannose-receptor-rich MDA-MB-231 breast cancer cells via receptor-mediated endocytosis, facilitating singlet oxygen generation to trigger apoptosis in cancer cells upon red light irradiation. These nanoparticles exhibit excellent targeted delivery of the PS, leading to cancer cell death after irradiation both in vitro and in vivo.

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 Dates: 2016-11-252016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acsami.6b13612
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Title: ACS Applied Materials and Interfaces
  Abbreviation : ACS Appl. Mater. Interfaces
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 8 (49) Sequence Number: - Start / End Page: 33405 - 33411 Identifier: ISSN: 1944-8244