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  The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair

Corsini, N. S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., et al. (2009). The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell, 5(2), 178-190. doi:10.1016/j.stem.2009.05.004.

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 Creators:
Corsini, Nina S., Author
Sancho-Martinez, Ignacio, Author
Laudenklos, Sabrina1, Author           
Glagow, Desiree, Author
Kumar, Sachin, Author
Letellier, Elisabeth, Author
Koch, Philipp, Author
Teodorczyk, Marcin, Author
Kleber, Susanne, Author
Klussmann, Stefan, Author
Wiestler, Benedict, Author
Brüstle, Oliver, Author
Müller, Wolf, Author
Gieffers, Christian, Author
Hill, Oliver, Author
Thiemann, Meinolf, Author
Seedorf, Mathias, Author
Gretz, Norbert, Author
Sprengel, Rolf1, Author           
Celikel, Tansu2, Author           
Martin-Villalba, Ana, Author more..
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: STEMCELL
 Abstract: Adult neurogenesis persists in the subventricular zone and the dentate gyrus and can be induced upon central nervous system injury. However, the final contribution of newborn neurons to neuronal networks is limited. Here we show that in neural stem cells, stimulation of the "death receptor" CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and neuronal specification. These effects are mediated via activation of the Src/PI3K/AKT/mTOR signaling pathway, ultimately leading to a global increase in protein translation. Induction of neurogenesis by CD95 was further confirmed in the ischemic CA1 region, in the naive dentate gyrus, and after forced expression of CD95L in the adult subventricular zone. Lack of hippocampal CD95 resulted in a reduction in neurogenesis and working memory deficits. Following global ischemia, CD95-mediated brain repair rescued behavioral impairment. Thus, we identify the CD95/CD95L system as an instructive signal for ongoing and injury-induced neurogenesis.

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Language(s): eng - English
 Dates: 2009-02-092008-10-092009-05-072009-08-062009-08-07
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Cell Stem Cell
  Alternative Title : Cell Stem Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 5 (2) Sequence Number: - Start / End Page: 178 - 190 Identifier: ISSN: 1934-5909