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  Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

Beck, M., & Baumeister, W. (2016). Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail? Trends in Cell Biology, 26(11), 825-837. doi:10.1016/j.tcb.2016.08.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-18FC-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-18FD-F
Genre: Journal Article
Alternative Title : Review

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 Creators:
Beck, Martin1, Author
Baumeister, Wolfgang2, Author              
Affiliations:
1external, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: NUCLEAR-PORE COMPLEX; PATHOGEN LEPTOSPIRA-INTERROGANS; 26S PROTEASOME; STRUCTURAL-ANALYSIS; CRYO-EM; ELECTRON TOMOGRAPHY; ANGSTROM RESOLUTION; VISUAL PROTEOMICS; MASS-SPECTROMETRY; COATED VESICLESCell Biology;
 Abstract: Traditionally, macromolecular structure determination is performed ex situ, that is, with purified materials. But, there are strong incentives to develop approaches to study them in situ in their native functional context. In recent years, cryo-electron tomography (cryo-ET) has emerged as a powerful method for visualizing the molecular organization of unperturbed cellular landscapes with the potential to attain near-atomic resolution. Here, we review recent work on several macromolecular assemblies, demonstrating the power of in situ studies. We also highlight technical challenges and discuss ways to meet them.

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Language(s): eng - English
 Dates: 2016-09-232016
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000386983600009
DOI: 10.1016/j.tcb.2016.08.006
 Degree: -

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Title: Trends in Cell Biology
  Other : Trends Cell Biol.
  Subtitle : Special Issue: Future of Cell Biology
Source Genre: Journal
 Creator(s):
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Publ. Info: Cambridge, UK : Elsevier Current Trends
Pages: - Volume / Issue: 26 (11) Sequence Number: - Start / End Page: 825 - 837 Identifier: ISSN: 0962-8924
CoNE: /journals/resource/954925580131