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  Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

Sun, Z., Tseng, H.-Y., Tan, S., Senger, F., Kurzawa, L., Dedden, D., et al. (2016). Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation. Nature Cell Biology, 18(9), 941-953. doi:10.1038/ncb3402.

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 Creators:
Sun, Zhiqi1, Author              
Tseng, Hui-Yuan1, Author              
Tan, Steven2, Author
Senger, Fabrice2, Author
Kurzawa, Laetitia2, Author
Dedden, Dirk1, Author              
Mizuno, Naoko3, Author              
Wasik, Anita A.1, Author              
Thery, Manuel2, Author
Dunn, Alexander R.2, Author
Fässler, Reinhard1, Author              
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2external, ou_persistent22              
3Mizuno, Naoko / Cellular and Membrane Trafficking, Max Planck Institute of Biochemistry, Max Planck Society, ou_1688137              

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Free keywords: FOCAL ADHESIONS; CELL-ADHESION; MYOSIN-II; DYNAMICS; ACTIN; RIAM; VINCULIN; BETA(1); FIBROBLASTS; RECRUITMENTCell Biology;
 Abstract: Integrin-based adhesions play critical roles in cell migration. Talin activates integrins and flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a 'molecular clutch' that transmits forces to the extracellular matrix to drive cell migration. Here we identify the evolutionarily conserved Kank protein family as novel components of focal adhesions (FAs). Kank proteins accumulate at the lateral border of FAs, which we term the FA belt, and in central sliding adhesions, where they directly bind the talin rod domain through the Kank amino-terminal (KN) motif and induce talin and integrin activation. In addition, Kank proteins diminish the talin-actomyosin linkage, which curbs force transmission across integrins, leading to reduced integrin-ligand bond strength, slippage between integrin and ligand, central adhesion formation and sliding, and reduced cell migration speed. Our data identify Kank proteins as talin activators that decrease the grip between the integrin-talin complex and actomyosin to regulate cell migration velocity.

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Language(s): eng - English
 Dates: 2016-08-222016
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000382416800005
DOI: 10.1038/ncb3402
 Degree: -

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Title: Nature Cell Biology
  Other : 'Nat. Cell Biol.'
Source Genre: Journal
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Publ. Info: London : Macmillan Magazines Ltd.
Pages: - Volume / Issue: 18 (9) Sequence Number: - Start / End Page: 941 - 953 Identifier: ISSN: 1465-7392
CoNE: https://pure.mpg.de/cone/journals/resource/954925625310