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  Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: a case study on microgravity-caused changes in cells

Bauer, J., Bussen, M., Wise, P., Wehland, M., Schneider, S., & Grimm, D. (2016). Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: a case study on microgravity-caused changes in cells. Expert Review of Proteomics, 13(7), 697-705. doi:10.1080/14789450.2016.1197775.

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Bauer, Johann1, Author              
Bussen, Markus2, Author
Wise, Petra2, Author
Wehland, Markus2, Author
Schneider, Sabine1, Author              
Grimm, Daniela2, Author
Affiliations:
1Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565170              
2external, ou_persistent22              

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Free keywords: MESENCHYMAL STEM-CELLS; HUMAN ENDOTHELIAL-CELLS; ROTATING WALL VESSEL; BREAST-CANCER CELLS; INHIBITS OSTEOGENIC DIFFERENTIATION; PARABOLIC FLIGHT MANEUVERS; RANDOM POSITIONING MACHINE; ALTERED GRAVITY CONDITIONS; GLUCOSE-REGULATED PROTEIN; PROSTATE CARCINOMA-CELLSBiochemistry & Molecular Biology; Microgravity; protein contents; Pathway Studio analysis; biological processes; 3D cell growth; gene expression patterns;
 Abstract: Background: More than one hundred reports were published about the characterization of cells from malignant and healthy tissues, as well as of endothelial cells and stem cells exposed to microgravity conditions.Methods: We retrieved publications about microgravity related studies on each type of cells, extracted the proteins mentioned therein and analyzed them aiming to identify biological processes affected by microgravity culture conditions.Results: The analysis revealed 66 different biological processes, 19 of them were always detected when papers about the four types of cells were analyzed.Conclusion: Since a response to the removal of gravity is common to the different cell types, some of the 19 biological processes could play a role in cellular adaption to microgravity. Applying computer programs, to extract and analyze proteins and genes mentioned in publications becomes essential for scientists interested to get an overview of the rapidly growing fields of gravitational biology and space medicine.

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Language(s): eng - English
 Dates: 2016-06-172016
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Expert Review of Proteomics
Source Genre: Journal
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Publ. Info: London : Future Drugs Ltd.
Pages: - Volume / Issue: 13 (7) Sequence Number: - Start / End Page: 697 - 705 Identifier: ISSN: 1478-9450
CoNE: https://pure.mpg.de/cone/journals/resource/111087325416002